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Research Article

A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase

  • Lisa Sharling,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

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  • Xiaoping Liu,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

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  • Deviprasad R. Gollapalli,

    Affiliations: Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America, Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America

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  • Sushil K. Maurya,

    Affiliation: Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America

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  • Lizbeth Hedstrom,

    Affiliations: Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America, Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America

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  • Boris Striepen mail

    striepen@cb.uga.edu

    Affiliations: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America, Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

    X
  • Published: August 10, 2010
  • DOI: 10.1371/journal.pntd.0000794

About the Authors

Lisa Sharling, Xiaoping Liu, Boris Striepen
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
Deviprasad R. Gollapalli, Sushil K. Maurya
Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America
Deviprasad R. Gollapalli, Lizbeth Hedstrom
Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
Lizbeth Hedstrom
Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America
Boris Striepen
Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Corresponding Author

Email: striepen@cb.uga.edu

Competing Interests

Some of the authors of this paper are also listed on a patent application on the compounds described in this paper. The authors note that their primary goal in protecting the IP for the compounds is to ensure that they retain a chance to become actual drugs in the future. Unresolved IP often prevents further development of drugs. Nonetheless, the patent constitutes a potential competing interest.

Author Contributions

Conceived and designed the experiments: LS DRG LH BS. Performed the experiments: LS XL DRG. Analyzed the data: LS XL DRG LH BS. Contributed reagents/materials/analysis tools: DRG SKM. Wrote the paper: LS LH BS.