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Research Article

Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1

  • Jacob D. Durrant equal contributor,

    equal contributor Contributed equally to this work with: Jacob D. Durrant, Laurence Hall

    Affiliation: Biomedical Sciences Program, University of California San Diego, La Jolla, California, United States of America

    X
  • Laurence Hall equal contributor,

    equal contributor Contributed equally to this work with: Jacob D. Durrant, Laurence Hall

    Affiliation: Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Robert V. Swift,

    Affiliation: Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, United States of America

    X
  • Melissa Landon,

    Affiliation: Department of Biochemistry, Rosenstiel Basic Medical Sciences Center, Brandeis University, Waltham, Massachusetts, United States of America

    Current address: Cubist Pharmaceuticals, Inc., Lexington, Massachusetts, United States of America

    X
  • Achim Schnaufer mail,

    ramaro@uci.edu (REA); achim.schnaufer@ed.ac.uk (AS)

    Affiliation: Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Rommie E. Amaro mail

    ramaro@uci.edu (REA); achim.schnaufer@ed.ac.uk (AS)

    Affiliations: Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, United States of America, Department of Computer Science, University of California Irvine, Irvine, California, United States of America

    X
  • Published: August 24, 2010
  • DOI: 10.1371/journal.pntd.0000803

About the Authors

Jacob D. Durrant
Biomedical Sciences Program, University of California San Diego, La Jolla, California, United States of America
Laurence Hall, Achim Schnaufer
Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
Robert V. Swift, Rommie E. Amaro
Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, United States of America
Melissa Landon
Department of Biochemistry, Rosenstiel Basic Medical Sciences Center, Brandeis University, Waltham, Massachusetts, United States of America
Rommie E. Amaro
Department of Computer Science, University of California Irvine, Irvine, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDD RVS AS REA. Performed the experiments: JDD LH RVS ML AS REA. Analyzed the data: JDD LH RVS AS REA. Contributed reagents/materials/analysis tools: JDD ML RVS AS REA. Wrote the paper: JDD RVS ML AS REA.