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Research Article

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

  • Gregory J. Crowther mail,

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Dhanasekaran Shanmugam,

    Affiliation: Department of Biology and Penn Genomics Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Santiago J. Carmona,

    Affiliation: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, Buenos Aires, Argentina

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  • Maria A. Doyle,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia

    Current address: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

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  • Christiane Hertz-Fowler,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

    Current address: Centre for Genomic Research, School of Biological Science, University of Liverpool, Liverpool, United Kingdom

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  • Matthew Berriman,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Solomon Nwaka,

    Affiliation: Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

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  • Stuart A. Ralph mail,

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia

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  • David S. Roos mail,

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Department of Biology and Penn Genomics Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Wesley C. Van Voorhis mail,

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Fernán Agüero mail

    crowther@u.washington.edu (GJC); saralph@unimelb.edu.au (SAR); droos@sas.upenn.edu (DSR); wesley@uw.edu (WCVV); fernan@iib.unsam.edu.ar (FA)

    Affiliation: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, Buenos Aires, Argentina

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  • Published: August 24, 2010
  • DOI: 10.1371/journal.pntd.0000804

About the Authors

Gregory J. Crowther, Wesley C. Van Voorhis
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
Dhanasekaran Shanmugam, David S. Roos
Department of Biology and Penn Genomics Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Santiago J. Carmona, Fernán Agüero
Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, Buenos Aires, Argentina
Maria A. Doyle, Stuart A. Ralph
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia
Christiane Hertz-Fowler, Matthew Berriman
Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Solomon Nwaka
Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GJC DS MB SN SAR DSR WCVV FA. Performed the experiments: GJC DS SJC FA. Analyzed the data: GJC DS SJC SAR FA. Contributed reagents/materials/analysis tools: GJC DS SJC MAD CHF DSR WCVV FA. Wrote the paper: GJC DS SJC SN SAR DSR WCVV FA.