Advertisement
Research Article

Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)

  • Gerritje J. W. van der Windt,

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

    X
  • W. Joost Wiersinga,

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

    X
  • Catharina W. Wieland,

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

    X
  • Ivo C. S. I. Tjia,

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

    X
  • Nicholas P. Day,

    Affiliations: Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom

    X
  • Sharon J. Peacock,

    Affiliations: Mahidol University, Bangkok, Thailand, Department of Medicine, University of Cambridge, Cambridge, United Kingdom

    X
  • Sandrine Florquin,

    Affiliation: Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

    X
  • Tom van der Poll mail

    t.vanderpoll@amc.uva.nl

    Affiliations: Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands

    X
  • Published: August 31, 2010
  • DOI: 10.1371/journal.pntd.0000806

About the Authors

Gerritje J. W. van der Windt, W. Joost Wiersinga, Catharina W. Wieland, Ivo C. S. I. Tjia, Tom van der Poll
Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands
Gerritje J. W. van der Windt, W. Joost Wiersinga, Catharina W. Wieland, Ivo C. S. I. Tjia, Tom van der Poll
Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
Nicholas P. Day, Sharon J. Peacock
Mahidol University, Bangkok, Thailand
Nicholas P. Day
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom
Sharon J. Peacock
Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Sandrine Florquin
Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

Corresponding Author

Email: t.vanderpoll@amc.uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GJWvdW WJW CWW SF TvdP. Performed the experiments: GJWvdW WJW CWW ICSIT. Analyzed the data: GJWvdW WJW CWW SF TvdP. Contributed reagents/materials/analysis tools: GJWvdW NPD SJP TvdP. Wrote the paper: GJWvdW NPD SJP SF TvdP.