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Research Article

Leishmania-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition

  • Daniel P. Depledge,

    Affiliation: Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom

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  • Lorna M. MacLean,

    Affiliation: Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom

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  • Michael R. Hodgkinson,

    Affiliation: Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom

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  • Barbara A. Smith,

    Affiliation: Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom

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  • Andrew P. Jackson,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Saufung Ma,

    Affiliation: Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom

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  • Silvia R. B. Uliana,

    Affiliation: Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil

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  • Deborah F. Smith mail

    dfs501@york.ac.uk

    Affiliation: Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom

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  • Published: September 28, 2010
  • DOI: 10.1371/journal.pntd.0000829

About the Authors

Daniel P. Depledge, Lorna M. MacLean, Michael R. Hodgkinson, Barbara A. Smith, Saufung Ma, Deborah F. Smith
Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom
Andrew P. Jackson
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Silvia R. B. Uliana
Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil

Corresponding Author

Email: dfs501@york.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DPD SM DFS. Performed the experiments: DPD LMM MRH BAS SM SRBU. Analyzed the data: DPD LMM DFS. Contributed reagents/materials/analysis tools: APJ SRBU. Wrote the paper: DPD LMM DFS.