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Research Article

Systemic FasL and TRAIL Neutralisation Reduce Leishmaniasis Induced Skin Ulceration

  • Geremew Tasew equal contributor,

    equal contributor Contributed equally to this work with: Geremew Tasew, Susanne Nylén, Francesca Chiodi, Liv Eidsmo

    Affiliations: Ethiopian Health and Nutrition Research Institute (EHNRI), Parasitology Laboratory, Addis Ababa, Ethiopia, Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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  • Susanne Nylén equal contributor,

    equal contributor Contributed equally to this work with: Geremew Tasew, Susanne Nylén, Francesca Chiodi, Liv Eidsmo

    Affiliation: Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden

    X
  • Thorsten Lieke,

    Affiliations: Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden, Transplantationslabor, Klinik für Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany

    X
  • Befekadu Lemu,

    Affiliation: St. Paulos General Specialized Hospital, Addis Ababa, Ethiopia

    X
  • Hailu Meless,

    Affiliation: Ethiopian Health and Nutrition Research Institute (EHNRI), Parasitology Laboratory, Addis Ababa, Ethiopia

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  • Nicolas Ruffin,

    Affiliation: Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden

    X
  • Dawit Wolday,

    Affiliation: Ethiopian Health and Nutrition Research Institute (EHNRI), Parasitology Laboratory, Addis Ababa, Ethiopia

    X
  • Abraham Asseffa,

    Affiliation: Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia

    X
  • Hideo Yagita,

    Affiliation: Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

    X
  • Sven Britton,

    Affiliation: Unit of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

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  • Hannah Akuffo,

    Affiliation: Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden

    X
  • Francesca Chiodi equal contributor,

    equal contributor Contributed equally to this work with: Geremew Tasew, Susanne Nylén, Francesca Chiodi, Liv Eidsmo

    Affiliation: Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden

    X
  • Liv Eidsmo equal contributor mail

    equal contributor Contributed equally to this work with: Geremew Tasew, Susanne Nylén, Francesca Chiodi, Liv Eidsmo

    liv.eidsmo@ki.se

    Affiliations: Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden, Unit of Dermatology and Venerology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

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  • Published: October 12, 2010
  • DOI: 10.1371/journal.pntd.0000844

About the Authors

Geremew Tasew, Hailu Meless, Dawit Wolday
Ethiopian Health and Nutrition Research Institute (EHNRI), Parasitology Laboratory, Addis Ababa, Ethiopia
Geremew Tasew, Susanne Nylén, Thorsten Lieke, Nicolas Ruffin, Hannah Akuffo, Francesca Chiodi, Liv Eidsmo
Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Thorsten Lieke
Transplantationslabor, Klinik für Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
Befekadu Lemu
St. Paulos General Specialized Hospital, Addis Ababa, Ethiopia
Abraham Asseffa
Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia
Hideo Yagita
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Sven Britton
Unit of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Liv Eidsmo
Unit of Dermatology and Venerology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

Corresponding Author

Email: liv.eidsmo@ki.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HA LE. Performed the experiments: GT SN TL BL HM NR LE. Analyzed the data: GT SN SB HA FC LE. Contributed reagents/materials/analysis tools: BL HM DW AA HY SB HA FC LE. Wrote the paper: GT FC LE.