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Research Article

Biochemical Properties of a Novel Cysteine Protease of Plasmodium vivax, Vivapain-4

  • Byoung-Kuk Na equal contributor,

    equal contributor Contributed equally to this work with: Byoung-Kuk Na, Young-An Bae

    Affiliations: Department of Molecular Parasitology and Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea, Department of Parasitology and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea

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  • Young-An Bae equal contributor,

    equal contributor Contributed equally to this work with: Byoung-Kuk Na, Young-An Bae

    Affiliation: Department of Molecular Parasitology and Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea

    X
  • Young-Gun Zo,

    Affiliation: Department of Molecular Parasitology and Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea

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  • Youngchool Choe,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Seon-Hee Kim,

    Affiliation: Department of Molecular Parasitology and Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea

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  • Prashant V. Desai,

    Affiliation: Department of Medicinal Chemistry, National Center for Natural Products Research, University of Mississippi, University, Mississippi, United States of America

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  • Mitchell A. Avery,

    Affiliation: Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi, Unites States of America

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  • Charles S. Craik,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Tong-Soo Kim,

    Affiliation: Department of Parasitology, Inha University College of Medicine, Incheon, Korea

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  • Philip J. Rosenthal,

    Affiliation: Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Yoon Kong mail

    ykong@med.skku.ac.kr

    Affiliation: Department of Molecular Parasitology and Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea

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  • Published: October 12, 2010
  • DOI: 10.1371/journal.pntd.0000849

About the Authors

Byoung-Kuk Na, Young-An Bae, Young-Gun Zo, Seon-Hee Kim, Yoon Kong
Department of Molecular Parasitology and Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea
Byoung-Kuk Na
Department of Parasitology and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea
Youngchool Choe, Charles S. Craik
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
Prashant V. Desai
Department of Medicinal Chemistry, National Center for Natural Products Research, University of Mississippi, University, Mississippi, United States of America
Mitchell A. Avery
Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi, Unites States of America
Tong-Soo Kim
Department of Parasitology, Inha University College of Medicine, Incheon, Korea
Philip J. Rosenthal
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: ykong@med.skku.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BKN YAB YK. Performed the experiments: BKN YC SHK PVD MAA CSC. Analyzed the data: BKN YAB YGZ SHK TSK PJR YK. Wrote the paper: YAB YGZ PJR YK.