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Research Article

Transcriptional Responses of Leptospira interrogans to Host Innate Immunity: Significant Changes in Metabolism, Oxygen Tolerance, and Outer Membrane

  • Feng Xue,

    Affiliations: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China, Department of Medical Microbiology and Parasitology, Medical College, Zhejiang University School of Medicine, Hangzhou, China

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  • Haiyan Dong,

    Affiliations: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China, Department of Medical Microbiology and Parasitology, Medical College, Zhejiang University School of Medicine, Hangzhou, China

    X
  • Jinyu Wu,

    Affiliation: Zhejiang Provincial Key Laboratory of Medical Genetics, Institute of Biomedical Informatics, Wenzhou Medical College, Wenzhou, China

    X
  • Zuowei Wu,

    Affiliation: Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Weilin Hu,

    Affiliations: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China, Department of Medical Microbiology and Parasitology, Medical College, Zhejiang University School of Medicine, Hangzhou, China

    X
  • Aihua Sun,

    Affiliations: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China, Department of Medical Microbiology and Parasitology, Medical College, Zhejiang University School of Medicine, Hangzhou, China

    X
  • Bryan Troxell,

    Affiliation: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • X. Frank Yang,

    Affiliation: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

    X
  • Jie Yan mail

    med_bp@zju.edu.cn

    Affiliations: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China, Department of Medical Microbiology and Parasitology, Medical College, Zhejiang University School of Medicine, Hangzhou, China

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  • Published: October 26, 2010
  • DOI: 10.1371/journal.pntd.0000857

About the Authors

Feng Xue, Haiyan Dong, Weilin Hu, Aihua Sun, Jie Yan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China
Feng Xue, Haiyan Dong, Weilin Hu, Aihua Sun, Jie Yan
Department of Medical Microbiology and Parasitology, Medical College, Zhejiang University School of Medicine, Hangzhou, China
Jinyu Wu
Zhejiang Provincial Key Laboratory of Medical Genetics, Institute of Biomedical Informatics, Wenzhou Medical College, Wenzhou, China
Zuowei Wu
Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Bryan Troxell, X. Frank Yang
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Corresponding Author

Email: med_bp@zju.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FX JY. Performed the experiments: FX HD ZW WH AS. Analyzed the data: FX JW XFY. Contributed reagents/materials/analysis tools: FX JY. Wrote the paper: FX BT XFY JY.