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Research Article

Metabolomics to Unveil and Understand Phenotypic Diversity between Pathogen Populations

  • Ruben t'Kindt,

    Affiliations: Unit of Molecular Parasitology, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Richard A. Scheltema,

    Affiliation: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

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  • Andris Jankevics,

    Affiliations: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Kirstyn Brunker,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Suman Rijal,

    Affiliation: B.P. Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

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  • Jean-Claude Dujardin,

    Affiliations: Unit of Molecular Parasitology, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

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  • Rainer Breitling,

    Affiliations: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • David G. Watson,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Graham H. Coombs,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Saskia Decuypere mail

    sdecuypere@itg.be

    Affiliations: Unit of Molecular Parasitology, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Published: November 30, 2010
  • DOI: 10.1371/journal.pntd.0000904

About the Authors

Ruben t'Kindt, Jean-Claude Dujardin, Saskia Decuypere
Unit of Molecular Parasitology, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
Ruben t'Kindt, Kirstyn Brunker, David G. Watson, Graham H. Coombs, Saskia Decuypere
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
Richard A. Scheltema, Andris Jankevics, Rainer Breitling
Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
Andris Jankevics, Rainer Breitling
Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Suman Rijal
B.P. Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal
Jean-Claude Dujardin
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

Corresponding Author

Email: sdecuypere@itg.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RtK RAS SR JCD RB DGW GHC SD. Performed the experiments: RtK KB. Analyzed the data: RtK RAS AJ DGW SD. Contributed reagents/materials/analysis tools: RtK RAS AJ. Wrote the paper: RtK RAS AJ KB SR JCD RB DGW GHC SD.