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Research Article

Temporal Fluctuation of Multidrug Resistant Salmonella Typhi Haplotypes in the Mekong River Delta Region of Vietnam

  • Kathryn E. Holt equal contributor mail,

    equal contributor Contributed equally to this work with: Kathryn E. Holt, Christiane Dolecek

    kholt@unimelb.edu.au

    Affiliations: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia

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  • Christiane Dolecek equal contributor,

    equal contributor Contributed equally to this work with: Kathryn E. Holt, Christiane Dolecek

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Tran Thuy Chau,

    Affiliation: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Pham Thanh Duy,

    Affiliation: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Tran Thi Phi La,

    Affiliation: An Giang Provincial Hospital, My Binh, Long Xuyen, An Giang, Vietnam

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  • Nguyen Van Minh Hoang,

    Affiliation: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Tran Vu Thieu Nga,

    Affiliation: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • James I. Campbell,

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom

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  • Bui Huu Manh,

    Affiliation: National Institute of Infectious and Tropical Diseases, Wellcome Trust Overseas Program, Oxford University Clinical Research Unit, Dong Da, Ha Noi, Vietnam

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  • Nguyen Van Vinh Chau,

    Affiliation: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Tran Tinh Hien,

    Affiliation: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Jeremy Farrar,

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom

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  • Gordon Dougan,

    Affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Stephen Baker

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom

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  • Published: January 04, 2011
  • DOI: 10.1371/journal.pntd.0000929

About the Authors

Kathryn E. Holt, Gordon Dougan
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
Kathryn E. Holt
Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia
Christiane Dolecek, Tran Thuy Chau, Pham Thanh Duy, Nguyen Van Minh Hoang, Tran Vu Thieu Nga, James I. Campbell, Jeremy Farrar, Stephen Baker
The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
Christiane Dolecek, James I. Campbell, Jeremy Farrar, Stephen Baker
Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom
Christiane Dolecek
London School of Hygiene and Tropical Medicine, London, United Kingdom
Tran Thi Phi La
An Giang Provincial Hospital, My Binh, Long Xuyen, An Giang, Vietnam
Bui Huu Manh
National Institute of Infectious and Tropical Diseases, Wellcome Trust Overseas Program, Oxford University Clinical Research Unit, Dong Da, Ha Noi, Vietnam
Nguyen Van Vinh Chau, Tran Tinh Hien
The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Corresponding Author

Email: kholt@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KEH CD NVVC TTH JF GD SB. Performed the experiments: TTC PTD TTPL NVMH TVTN JIC BHM NVVC. Analyzed the data: KEH CD BHM SB. Contributed reagents/materials/analysis tools: TTPL GD. Wrote the paper: KEH CD NVVC TTH JF GD SB.