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Research Article

BALB/c Mice Deficient in CD4+ T Cell IL-4Rα Expression Control Leishmania mexicana Load although Female but Not Male Mice Develop a Healer Phenotype

  • Karen J. Bryson,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Owain R. Millington,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Thabang Mokgethi,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • H. Adrienne McGachy,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Frank Brombacher,

    Affiliation: Institute of Infectious Diseases and Molecular Medicine, Health Science Faculty, University of Cape Town, Cape Town, South Africa

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  • James Alexander mail

    j.alexander@strath.ac.uk

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Published: January 04, 2011
  • DOI: 10.1371/journal.pntd.0000930

About the Authors

Karen J. Bryson, Owain R. Millington, Thabang Mokgethi, H. Adrienne McGachy, James Alexander
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
Frank Brombacher
Institute of Infectious Diseases and Molecular Medicine, Health Science Faculty, University of Cape Town, Cape Town, South Africa

Corresponding Author

Email: j.alexander@strath.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FB JA. Performed the experiments: KJB ORM TM HAM JA. Analyzed the data: KJB ORM HAM JA. Contributed reagents/materials/analysis tools: FB JA. Wrote the paper: ORM FB JA.