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Research Article

Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System

  • Yaneth Osorio,

    Affiliations: Department of Veterans Affairs Medical Center, Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America

    Current address: Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Bruno L. Travi,

    Affiliations: Department of Veterans Affairs Medical Center, Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America

    Current address: Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Adam R. Renslo,

    Affiliation: Small Molecule Discovery Center, Sandler Center for Basic Research in Parasitic Diseases, and Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

    X
  • Alex G. Peniche,

    Affiliations: Department of Veterans Affairs Medical Center, Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America

    Current address: Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Peter C. Melby mail

    pcmelby@utmb.edu

    Affiliations: Department of Veterans Affairs Medical Center, Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Microbiology and Immunology, The University of Texas Health Science Center, San Antonio, Texas, United States of America

    Current address: Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Published: February 15, 2011
  • DOI: 10.1371/journal.pntd.0000962

About the Authors

Yaneth Osorio, Bruno L. Travi, Alex G. Peniche, Peter C. Melby
Department of Veterans Affairs Medical Center, Research Service, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
Yaneth Osorio, Bruno L. Travi, Alex G. Peniche, Peter C. Melby
Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas, United States of America
Adam R. Renslo
Small Molecule Discovery Center, Sandler Center for Basic Research in Parasitic Diseases, and Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America
Peter C. Melby
Department of Microbiology and Immunology, The University of Texas Health Science Center, San Antonio, Texas, United States of America

Corresponding Author

Email: pcmelby@utmb.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YO BLT PCM. Performed the experiments: YO AGP. Analyzed the data: YO BLT ARR AGP PCM. Wrote the paper: YO BLT ARR AGP PCM.