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Research Article

Enzymatic Shaving of the Tegument Surface of Live Schistosomes for Proteomic Analysis: A Rational Approach to Select Vaccine Candidates

  • William Castro-Borges mail,

    williamcborges@hotmail.com

    Affiliation: Department of Biology, University of York, Heslington, York, United Kingdom

    Current address: Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, Brasil

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  • Adam Dowle,

    Affiliation: Department of Biology and Centre of Excellence in Mass Spectrometry, Technology Facility, University of York, Heslington, York, United Kingdom

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  • Rachel S. Curwen,

    Affiliation: Department of Biology, University of York, Heslington, York, United Kingdom

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  • Jane Thomas-Oates,

    Affiliation: Department of Chemistry and Centre of Excellence in Mass Spectrometry, University of York, Heslington, York, United Kingdom

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  • R. Alan Wilson

    Affiliation: Department of Biology, University of York, Heslington, York, United Kingdom

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  • Published: March 29, 2011
  • DOI: 10.1371/journal.pntd.0000993

About the Authors

William Castro-Borges, Rachel S. Curwen, R. Alan Wilson
Department of Biology, University of York, Heslington, York, United Kingdom
Adam Dowle
Department of Biology and Centre of Excellence in Mass Spectrometry, Technology Facility, University of York, Heslington, York, United Kingdom
Jane Thomas-Oates
Department of Chemistry and Centre of Excellence in Mass Spectrometry, University of York, Heslington, York, United Kingdom

Corresponding Author

Email: williamcborges@hotmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WC-B RSC JT-O RAW. Performed the experiments: WC-B AD. Analyzed the data: WC-B AD RAW. Contributed reagents/materials/analysis tools: JT-O RAW. Wrote the paper: WC-B RAW.