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Research Article

Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica

  • Mark W. Robinson mail,

    mark.robinson@uts.edu.au

    Affiliation: Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney (UTS), Sydney, New South Wales, Australia

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  • Ileana Corvo,

    Affiliation: Departmento de Genética, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay

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  • Peter M. Jones,

    Affiliation: Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney (UTS), Sydney, New South Wales, Australia

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  • Anthony M. George,

    Affiliation: Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney (UTS), Sydney, New South Wales, Australia

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  • Matthew P. Padula,

    Affiliation: Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney (UTS), Sydney, New South Wales, Australia

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  • Joyce To,

    Affiliation: Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney (UTS), Sydney, New South Wales, Australia

    X
  • Martin Cancela,

    Affiliation: Departmento de Genética, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay

    Current address: Laboratorio de Cestodeos, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

    X
  • Gabriel Rinaldi,

    Affiliation: Departmento de Genética, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay

    Current address: Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC, United States of America

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  • Jose F. Tort,

    Affiliation: Departmento de Genética, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay

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  • Leda Roche,

    Affiliation: Departmento de Genética, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay

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  • John P. Dalton

    Affiliation: Institute of Parasitology, McGill University, St. Anne de Bellevue, Quebec, Canada

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  • Published: April 05, 2011
  • DOI: 10.1371/journal.pntd.0001012

About the Authors

Mark W. Robinson, Peter M. Jones, Anthony M. George, Matthew P. Padula, Joyce To
Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney (UTS), Sydney, New South Wales, Australia
Ileana Corvo, Martin Cancela, Gabriel Rinaldi, Jose F. Tort, Leda Roche
Departmento de Genética, Facultad de Medicina, Universidad de la República (UDELAR), Montevideo, Uruguay
John P. Dalton
Institute of Parasitology, McGill University, St. Anne de Bellevue, Quebec, Canada

Corresponding Author

Email: mark.robinson@uts.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MWR IC PMJ AMG MC GR JFT LR JPD. Performed the experiments: MWR IC PMJ MPP JT. Analyzed the data: MWR IC PMJ MPP JFT JPD. Contributed reagents/materials/analysis tools: MWR IC PMJ JPD. Wrote the paper: MWR PMJ JPD.