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Research Article

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

  • Kenny K. H. Ang,

    Affiliation: The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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  • Joseline Ratnam,

    Affiliation: The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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  • Jiri Gut,

    Affiliation: Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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  • Jennifer Legac,

    Affiliation: Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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  • Elizabeth Hansell,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Zachary B. Mackey,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Katarzyna M. Skrzypczynska,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Anjan Debnath,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Juan C. Engel,

    Affiliation: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Philip J. Rosenthal,

    Affiliation: Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

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  • James H. McKerrow,

    Affiliations: The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

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  • Michelle R. Arkin mail,

    michelle.arkin@ucsf.edu (MRA); adam.renslo@ucsf.edu (ARR)

    Affiliations: The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Adam R. Renslo mail

    michelle.arkin@ucsf.edu (MRA); adam.renslo@ucsf.edu (ARR)

    Affiliations: The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Published: May 03, 2011
  • DOI: 10.1371/journal.pntd.0001023

About the Authors

Kenny K. H. Ang, Joseline Ratnam, Michelle R. Arkin, Adam R. Renslo
The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America
Jiri Gut, Jennifer Legac, Philip J. Rosenthal
Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
Elizabeth Hansell, Zachary B. Mackey, Katarzyna M. Skrzypczynska, Anjan Debnath, Juan C. Engel, James H. McKerrow
The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America
James H. McKerrow
Department of Pathology, University of California San Francisco, San Francisco, California, United States of America
Michelle R. Arkin, Adam R. Renslo
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KKHA JR JG JL EH ZBM KMS AD JCE. Performed the experiments: KKHA JR JG JL EH ZBM KMS AD JCE. Analyzed the data: KKHA JR JG JL EH ZBM KMS AD JCE PJR JHM MRA ARR. Contributed reagents/materials/analysis tools: JR JG JL EH ZBM KMS AD JCE. Wrote the paper: PJR JHM MRA ARR.