Advertisement
Research Article

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

  • Roderick G. Walker,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    X
  • Graeme Thomson,

    Affiliation: Cyclacel Ltd., Dundee, Dundee, United Kingdom

    X
  • Kirk Malone,

    Affiliation: Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom

    X
  • Matthew W. Nowicki,

    Affiliation: Institute of Structural and Molecular Biology, The University of Edinburgh, Edinburgh, United Kingdom

    X
  • Elaine Brown,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    X
  • David G. Blake,

    Affiliation: Cyclacel Ltd., Dundee, Dundee, United Kingdom

    X
  • Nicholas J. Turner,

    Affiliation: Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom

    X
  • Malcolm D. Walkinshaw,

    Affiliation: Institute of Structural and Molecular Biology, The University of Edinburgh, Edinburgh, United Kingdom

    X
  • Karen M. Grant,

    Affiliation: School of Health & Medicine, Division of Medicine, Lancaster University, Lancaster, United Kingdom

    X
  • Jeremy C. Mottram mail

    j.mottram@udcf.gla.ac.uk

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    X
  • Published: April 05, 2011
  • DOI: 10.1371/journal.pntd.0001033

About the Authors

Roderick G. Walker, Elaine Brown, Jeremy C. Mottram
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Graeme Thomson, David G. Blake
Cyclacel Ltd., Dundee, Dundee, United Kingdom
Kirk Malone, Nicholas J. Turner
Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
Matthew W. Nowicki, Malcolm D. Walkinshaw
Institute of Structural and Molecular Biology, The University of Edinburgh, Edinburgh, United Kingdom
Karen M. Grant
School of Health & Medicine, Division of Medicine, Lancaster University, Lancaster, United Kingdom

Corresponding Author

Email: j.mottram@udcf.gla.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RGW GT KM MWN NJT MDW KMG JCM. Performed the experiments: RGW GT KM MWN EB. Analyzed the data: RGW GT KM MWN EB DGB NJT MDW KMG JCM. Wrote the paper: RGW MWN DGB KMG JCM.