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Research Article

Solution Structure of a Repeated Unit of the ABA-1 Nematode Polyprotein Allergen of Ascaris Reveals a Novel Fold and Two Discrete Lipid-Binding Sites

  • Nicola A. G. Meenan,

    Affiliation: School of Chemistry, University of Glasgow, Glasgow, Scotland, United Kingdom

    Current address: Thomson Reuters (Scientific UK), Leeds, United Kingdom

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  • Graeme Ball,

    Affiliation: Edinburgh Biomolecular NMR Unit, School of Chemistry, University of Edinburgh, Edinburgh, Scotland, United Kingdom

    Current address: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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  • Krystyna Bromek,

    Affiliation: Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, Scotland, United Kingdom

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  • Dušan Uhrín,

    Affiliation: Edinburgh Biomolecular NMR Unit, School of Chemistry, University of Edinburgh, Edinburgh, Scotland, United Kingdom

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  • Alan Cooper,

    Affiliation: School of Chemistry, University of Glasgow, Glasgow, Scotland, United Kingdom

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  • Malcolm W. Kennedy mail,

    Brian.Smith@glasgow.ac.uk (BOS); malcolm.kennedy@glasgow.ac.uk (MWK)

    Affiliations: Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, Scotland, United Kingdom, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom

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  • Brian O. Smith mail

    Brian.Smith@glasgow.ac.uk (BOS); malcolm.kennedy@glasgow.ac.uk (MWK)

    Affiliation: Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, Scotland, United Kingdom

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  • Published: April 19, 2011
  • DOI: 10.1371/journal.pntd.0001040

About the Authors

Nicola A. G. Meenan, Alan Cooper
School of Chemistry, University of Glasgow, Glasgow, Scotland, United Kingdom
Graeme Ball, Dušan Uhrín
Edinburgh Biomolecular NMR Unit, School of Chemistry, University of Edinburgh, Edinburgh, Scotland, United Kingdom
Krystyna Bromek, Malcolm W. Kennedy, Brian O. Smith
Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, Scotland, United Kingdom
Malcolm W. Kennedy
Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NAGM DU AC MWK BOS. Performed the experiments: NAGM AC MWK BOS. Analyzed the data: NAGM GB KB AC MWK BOS. Contributed reagents/materials/analysis tools: NAGM GB KB DU AC MWK BOS. Wrote the paper: NAGM AC MWK BOS.