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Research Article

A Phase Two Randomised Controlled Double Blind Trial of High Dose Intravenous Methylprednisolone and Oral Prednisolone versus Intravenous Normal Saline and Oral Prednisolone in Individuals with Leprosy Type 1 Reactions and/or Nerve Function Impairment

  • Stephen L. Walker mail,

    steve.walker@lshtm.ac.uk

    Affiliation: Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Peter G. Nicholls,

    Affiliation: School of Health Sciences, University of Southampton, Southampton, United Kingdom

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  • Sushmita Dhakal,

    Affiliation: Anandaban Hospital, Kathmandu, Nepal

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  • Rachel A. Hawksworth,

    Affiliation: Anandaban Hospital, Kathmandu, Nepal

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  • Murdo Macdonald,

    Affiliation: Anandaban Hospital, Kathmandu, Nepal

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  • Kishori Mahat,

    Affiliation: Anandaban Hospital, Kathmandu, Nepal

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  • Shudan Ruchal,

    Affiliation: Anandaban Hospital, Kathmandu, Nepal

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  • Sushma Hamal,

    Affiliation: Anandaban Hospital, Kathmandu, Nepal

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  • Deanna A. Hagge,

    Affiliation: Anandaban Hospital, Kathmandu, Nepal

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  • Kapil D. Neupane,

    Affiliation: Anandaban Hospital, Kathmandu, Nepal

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  • Diana N. J. Lockwood

    Affiliation: Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Published: April 12, 2011
  • DOI: 10.1371/journal.pntd.0001041

About the Authors

Stephen L. Walker, Diana N. J. Lockwood
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Peter G. Nicholls
School of Health Sciences, University of Southampton, Southampton, United Kingdom
Sushmita Dhakal, Rachel A. Hawksworth, Murdo Macdonald, Kishori Mahat, Shudan Ruchal, Sushma Hamal, Deanna A. Hagge, Kapil D. Neupane
Anandaban Hospital, Kathmandu, Nepal

Corresponding Author

Email: steve.walker@lshtm.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SLW PGN RAH MM DNJL. Performed the experiments: SLW SD RAH KM SR SH. Analyzed the data: SLW PGN. Contributed reagents/materials/analysis tools: SLW DNJL. Wrote the paper: SLW DNJL. Coordinated the study: SLW RAH MM DAH KDN.