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Research Article

Effect of BMAP-28 Antimicrobial Peptides on Leishmania major Promastigote and Amastigote Growth: Role of Leishmanolysin in Parasite Survival

  • Miriam A. Lynn,

    Affiliation: Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, and the Department of Medical Genetics, Vancouver, Canada

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  • Jason Kindrachuk,

    Affiliation: Centre for Microbial Diseases and Immunity Research and the Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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  • Alexandra K. Marr,

    Affiliation: Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, and the Department of Medical Genetics, Vancouver, Canada

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  • Håvard Jenssen,

    Affiliations: Centre for Microbial Diseases and Immunity Research and the Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada, Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark

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  • Nelly Panté,

    Affiliation: Department of Zoology, University of British Columbia, Vancouver, Canada

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  • Melissa R. Elliott,

    Affiliation: Centre for Microbial Diseases and Immunity Research and the Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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  • Scott Napper,

    Affiliations: Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada, Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada

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  • Robert E. Hancock,

    Affiliation: Centre for Microbial Diseases and Immunity Research and the Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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  • W. Robert McMaster mail

    robm@interchange.ubc.ca

    Affiliation: Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, and the Department of Medical Genetics, Vancouver, Canada

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  • Published: May 31, 2011
  • DOI: 10.1371/journal.pntd.0001141

About the Authors

Miriam A. Lynn, Alexandra K. Marr, W. Robert McMaster
Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, and the Department of Medical Genetics, Vancouver, Canada
Jason Kindrachuk, Håvard Jenssen, Melissa R. Elliott, Robert E. Hancock
Centre for Microbial Diseases and Immunity Research and the Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
Håvard Jenssen
Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark
Nelly Panté
Department of Zoology, University of British Columbia, Vancouver, Canada
Scott Napper
Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada
Scott Napper
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada

Corresponding Author

Email: robm@interchange.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAL JK AKM HJ NP MRE SN REH WRM. Performed the experiments: MAL JK AKM HJ NP MRE SN. Analyzed the data: MAL JK AKM HJ NP MRE SN REH WRM. Wrote the paper: MAL JK REH WRM.