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Research Article

Preclinical Evaluation of Caprylic Acid-Fractionated IgG Antivenom for the Treatment of Taipan (Oxyuranus scutellatus) Envenoming in Papua New Guinea

  • Mariángela Vargas,

    Affiliation: Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

    X
  • Alvaro Segura,

    Affiliation: Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

    X
  • María Herrera,

    Affiliation: Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

    X
  • Mauren Villalta,

    Affiliation: Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

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  • Ricardo Estrada,

    Affiliation: Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

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  • Maykel Cerdas,

    Affiliation: Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

    X
  • Owen Paiva,

    Affiliation: School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea

    X
  • Teatulohi Matainaho,

    Affiliation: School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea

    X
  • Simon D. Jensen,

    Affiliations: School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea, Australian Venom Research Unit, University of Melbourne, Parkville, Australia

    X
  • Kenneth D. Winkel,

    Affiliation: Australian Venom Research Unit, University of Melbourne, Parkville, Australia

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  • Guillermo León,

    Affiliation: Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

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  • José María Gutiérrez mail,

    jose.gutierrez@ucr.ac.cr

    Affiliation: Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

    X
  • David J. Williams

    Affiliations: School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea, Australian Venom Research Unit, University of Melbourne, Parkville, Australia, Nossal Institute for Global Health, University of Melbourne, Parkville, Australia

    X
  • Published: May 17, 2011
  • DOI: 10.1371/journal.pntd.0001144

About the Authors

Mariángela Vargas, Alvaro Segura, María Herrera, Mauren Villalta, Ricardo Estrada, Maykel Cerdas, Guillermo León, José María Gutiérrez
Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
Owen Paiva, Teatulohi Matainaho, Simon D. Jensen, David J. Williams
School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea
Simon D. Jensen, Kenneth D. Winkel, David J. Williams
Australian Venom Research Unit, University of Melbourne, Parkville, Australia
David J. Williams
Nossal Institute for Global Health, University of Melbourne, Parkville, Australia

Corresponding Author

Email: jose.gutierrez@ucr.ac.cr

Competing Interests

Mariángela Vargas, Alvaro Segura, María Herrera, Mauren Villalta, Ricardo Estrada, Maykel Cerdas, Guillermo León and José María Gutiérrez work at Instituto Clodomiro Picado, Universidad de Costa Rica, where one of the antivenoms tested in this study was produced.

Author Contributions

Conceived and designed the experiments: M Vargas A Segura M Herrera M Villalta R Estrada KD Winkel G León JM Gutiérrez DJ Williams. Performed the experiments: M Vargas A Segura M Herrera M Villalta R Estrada M Cerdas G León DJ Williams. Analyzed the data: M Vargas A Segura M Herrera M Villalta O Paiva T Matainaho SD Jensen KD Winkel G León JM Gutiérrez DJ Williams. Wrote the paper: O Paiva SD Jensen KD Winkel G León JM Gutiérrez DJ Williams.