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Research Article

Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation

  • Sabine Kuettel,

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland

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  • Jason Greenwald,

    Affiliation: Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland

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  • Dirk Kostrewa,

    Affiliation: Gene Center Munich, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany

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  • Shaheen Ahmed,

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland

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  • Leonardo Scapozza mail,

    leonardo.scapozza@unige.ch (LS); remo.perozzo@unige.ch (RP)

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland

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  • Remo Perozzo mail

    leonardo.scapozza@unige.ch (LS); remo.perozzo@unige.ch (RP)

    Affiliation: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland

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  • Published: May 24, 2011
  • DOI: 10.1371/journal.pntd.0001164

About the Authors

Sabine Kuettel, Shaheen Ahmed, Leonardo Scapozza, Remo Perozzo
Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland
Jason Greenwald
Laboratory of Physical Chemistry, ETH Zurich, Zurich, Switzerland
Dirk Kostrewa
Gene Center Munich, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SK LS RP. Performed the experiments: SK JG DK SA RP. Analyzed the data: SK SA LS RP. Wrote the paper: SK SA LS RP.