Advertisement
Research Article

A Multicentre Randomized Controlled Trial of the Efficacy and Safety of Single-Dose Praziquantel at 40 mg/kg vs. 60 mg/kg for Treating Intestinal Schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil

  • Piero L. Olliaro,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland

    X
  • Michel T. Vaillant mail,

    michel.vaillant@crp-sante.lu

    Affiliation: Methodology and Statistical Unit, Center for Health Studies, Centre de Recherche – Santé, Strassen, Luxembourg

    X
  • Vincente J. Belizario,

    Affiliation: National Institutes of Health, University of the Philippines Manila, Manila, Philippines

    X
  • Nicholas J. S. Lwambo †,

    † Deceased.

    Affiliation: National Institute for Medical Research, Mwanza Medical Research Centre, Mwanza, Tanzania

    X
  • Mohamed Ouldabdallahi,

    Affiliation: Nutrition et Actes Médicaux, Institut National de Recherches en Santé Publique (INRSP), Nouakchott, Mauritania

    X
  • Otavio S. Pieri,

    Affiliation: Laboratorio de Eco-Epidemiologia e Controle da Esquistossomose e Geohelmintoses, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil

    X
  • Maria L. Amarillo,

    Affiliation: Department of Clinical Epidemiology, College of Medicine, University of the Philippines, Manila, Philippines

    X
  • Godfrey M. Kaatano,

    Affiliation: National Institute for Medical Research, Mwanza Medical Research Centre, Mwanza, Tanzania

    X
  • Mamadou Diaw,

    Affiliation: Ministère de la Santé/P.E.V., Nouakchott, Mauritania

    X
  • AnaLucia C. Domingues,

    Affiliation: Departamento de Medicina Clinica, Centro de Ciencias da Saude, UFPE, Hospital das Clinicas, Recife, Brazil

    X
  • Tereza C. Favre,

    Affiliation: Laboratorio de Eco-Epidemiologia e Controle da Esquistossomose e Geohelmintoses, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil

    X
  • Olivier Lapujade,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland

    X
  • Fabiana Alves,

    Affiliation: Latin America Regional Office, Drugs for Neglected Diseases Initiative, Rio de Janeiro, Brazil

    X
  • Lester Chitsulo

    Affiliation: Preventive Chemotherapy and Transmission Control Unit, Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland

    X
  • Published: June 14, 2011
  • DOI: 10.1371/journal.pntd.0001165

About the Authors

Piero L. Olliaro, Olivier Lapujade
UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland
Michel T. Vaillant
Methodology and Statistical Unit, Center for Health Studies, Centre de Recherche – Santé, Strassen, Luxembourg
Vincente J. Belizario
National Institutes of Health, University of the Philippines Manila, Manila, Philippines
Nicholas J. S. Lwambo, Godfrey M. Kaatano
National Institute for Medical Research, Mwanza Medical Research Centre, Mwanza, Tanzania
Mohamed Ouldabdallahi
Nutrition et Actes Médicaux, Institut National de Recherches en Santé Publique (INRSP), Nouakchott, Mauritania
Otavio S. Pieri, Tereza C. Favre
Laboratorio de Eco-Epidemiologia e Controle da Esquistossomose e Geohelmintoses, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
Maria L. Amarillo
Department of Clinical Epidemiology, College of Medicine, University of the Philippines, Manila, Philippines
Mamadou Diaw
Ministère de la Santé/P.E.V., Nouakchott, Mauritania
AnaLucia C. Domingues
Departamento de Medicina Clinica, Centro de Ciencias da Saude, UFPE, Hospital das Clinicas, Recife, Brazil
Fabiana Alves
Latin America Regional Office, Drugs for Neglected Diseases Initiative, Rio de Janeiro, Brazil
Lester Chitsulo
Preventive Chemotherapy and Transmission Control Unit, Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland

Corresponding Author

Email: michel.vaillant@crp-sante.lu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LC PLO FA OL. Performed the experiments: VJB NJSL MO OSP. Analyzed the data: MTV PLO. Wrote the paper: PLO MTV. Principal investigators: VJB NJSL MO OSP. Protocol preparation, supervision of clinical and parasitological conduct, contribution to interpretation of results: ALCD TCF. Participation in finalization of master protocol (GCP) and GCP training of sites: OL. Preparation of master study protocol and sites preparation: FA. Initiation and coordination of the study, contribution to the preparation of the manuscipt: LC. Analytical protocol, report: MTV. Coordination and supervision of study conduct, analytical protocol, report: PLO.