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Research Article

Inconsistent Protective Efficacy and Marked Polymorphism Limits the Value of Schistosoma japonicum Tetraspanin-2 as a Vaccine Target

  • Wenbao Zhang,

    Affiliation: Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Jun Li,

    Affiliation: Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Mary Duke,

    Affiliation: Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Malcolm K. Jones,

    Affiliations: Parasite Cell Biology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, The School of Veterinary Science, The University of Queensland, St Lucia, Queensland, Australia

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  • Ling Kuang,

    Affiliation: Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Jianfeng Zhang,

    Affiliation: Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • David Blair,

    Affiliation: School of Marine and Tropical Biology, James Cook University, Townsville, Queensland, Australia

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  • Yuesheng Li,

    Affiliations: Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, Hunan Institute of Parasitic Diseases, Yueyang, China

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  • Donald P. McManus mail

    donM@qimr.edu.au

    Affiliation: Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Published: May 31, 2011
  • DOI: 10.1371/journal.pntd.0001166

About the Authors

Wenbao Zhang, Jun Li, Mary Duke, Ling Kuang, Jianfeng Zhang, Yuesheng Li, Donald P. McManus
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Malcolm K. Jones
Parasite Cell Biology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Malcolm K. Jones
The School of Veterinary Science, The University of Queensland, St Lucia, Queensland, Australia
David Blair
School of Marine and Tropical Biology, James Cook University, Townsville, Queensland, Australia
Yuesheng Li
Hunan Institute of Parasitic Diseases, Yueyang, China

Corresponding Author

Email: donM@qimr.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WZ DPM. Performed the experiments: WZ MD JL LK JZ. Analyzed the data: WZ JL DB MKJ DPM. Contributed reagents/materials/analysis tools: WZ JL MD DB YL MKJ. Wrote the paper: WZ DB DPM.