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Research Article

In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection

  • Ruklanthi de Alwis,

    Affiliation: Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Martina Beltramello,

    Affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland

    X
  • William B. Messer,

    Affiliation: Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Soila Sukupolvi-Petty,

    Affiliation: Departments of Medicine, Molecular Microbiology, Pathology and Immunology, and the Midwest Regional Center for Biodefense and Emerging Infectious Diseases Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Wahala M. P. B. Wahala,

    Affiliation: Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Annette Kraus,

    Affiliation: Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Nicholas P. Olivarez,

    Affiliation: Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Quang Pham,

    Affiliation: Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • James Brian,

    Affiliation: Departments of Medicine, Molecular Microbiology, Pathology and Immunology, and the Midwest Regional Center for Biodefense and Emerging Infectious Diseases Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Wen-Yang Tsai,

    Affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

    X
  • Wei-Kung Wang,

    Affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

    X
  • Scott Halstead,

    Affiliation: Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Korea

    X
  • Srisakul Kliks,

    Affiliation: Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Korea

    X
  • Michael S. Diamond,

    Affiliation: Departments of Medicine, Molecular Microbiology, Pathology and Immunology, and the Midwest Regional Center for Biodefense and Emerging Infectious Diseases Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Ralph Baric,

    Affiliation: Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Antonio Lanzavecchia,

    Affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland

    X
  • Federica Sallusto,

    Affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland

    X
  • Aravinda M. de Silva mail

    desilva@med.unc.edu

    Affiliation: Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Published: June 21, 2011
  • DOI: 10.1371/journal.pntd.0001188

About the Authors

Ruklanthi de Alwis, William B. Messer, Wahala M. P. B. Wahala, Annette Kraus, Nicholas P. Olivarez, Quang Pham, Ralph Baric, Aravinda M. de Silva
Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
Martina Beltramello, Antonio Lanzavecchia, Federica Sallusto
Institute for Research in Biomedicine, Bellinzona, Switzerland
Soila Sukupolvi-Petty, James Brian, Michael S. Diamond
Departments of Medicine, Molecular Microbiology, Pathology and Immunology, and the Midwest Regional Center for Biodefense and Emerging Infectious Diseases Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
Wen-Yang Tsai, Wei-Kung Wang
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America
Scott Halstead, Srisakul Kliks
Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Korea

Corresponding Author

Email: desilva@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RdA MB WBM S-SP WMPBW AK NPO QP JB W-YT W-KW SH SK MSD RB AL FS AMdS. Performed the experiments: RdA MB WBM S-SP WMPBW AK NPO QP JB W-YT W-KW. Analyzed the data: RdA MB WBM S-SP WMPBW AK NPO QP JB W-YT W-KW SH SK MSD RB AL FS AMdS. Contributed reagents/materials/analysis tools: AK MSD RB AL FS. Wrote the paper: RdA MB QP SH SK MSD RB AL FS AMdS.