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Research Article

Interferon-γ and Proliferation Responses to Salmonella enterica Serotype Typhi Proteins in Patients with S. Typhi Bacteremia in Dhaka, Bangladesh

  • Alaullah Sheikh mail,

    alaullah@icddrb.org

    Affiliations: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Farhana Khanam,

    Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Md. Abu Sayeed,

    Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Taibur Rahman,

    Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Marcin Pacek,

    Affiliation: Harvard Institute of Proteomics, Cambridge, Massachusetts, United States of America

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  • Yanhui Hu,

    Affiliation: Harvard Institute of Proteomics, Cambridge, Massachusetts, United States of America

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  • Andrea Rollins,

    Affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Md. Saruar Bhuiyan,

    Affiliations: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Sean Rollins,

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Anuj Kalsy,

    Affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Mohammad Arifuzzaman,

    Affiliations: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Daniel T. Leung,

    Affiliations: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • David A. Sarracino,

    Affiliation: Thermo Fisher Scientific, Cambridge, Massachusetts, United States of America

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  • Bryan Krastins,

    Affiliation: Thermo Fisher Scientific, Cambridge, Massachusetts, United States of America

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  • Richelle C. Charles,

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Regina C. LaRocque,

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Alejandro Cravioto,

    Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Stephen B. Calderwood,

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • W. Abdullah Brooks,

    Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Jason B. Harris,

    Affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Joshua LaBaer,

    Affiliations: Harvard Institute of Proteomics, Cambridge, Massachusetts, United States of America, Arizona State University, Tempe, Arizona, United States of America

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  • Firdausi Qadri equal contributor,

    equal contributor Contributed equally to this work with: Firdausi Qadri, Edward T. Ryan

    Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Edward T. Ryan equal contributor

    equal contributor Contributed equally to this work with: Firdausi Qadri, Edward T. Ryan

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Published: June 07, 2011
  • DOI: 10.1371/journal.pntd.0001193

About the Authors

Alaullah Sheikh, Farhana Khanam, Md. Abu Sayeed, Taibur Rahman, Md. Saruar Bhuiyan, Mohammad Arifuzzaman, Daniel T. Leung, Alejandro Cravioto, W. Abdullah Brooks, Firdausi Qadri
International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh
Alaullah Sheikh, Andrea Rollins, Md. Saruar Bhuiyan, Sean Rollins, Anuj Kalsy, Mohammad Arifuzzaman, Daniel T. Leung, Richelle C. Charles, Regina C. LaRocque, Stephen B. Calderwood, Jason B. Harris, Edward T. Ryan
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Marcin Pacek, Yanhui Hu, Joshua LaBaer
Harvard Institute of Proteomics, Cambridge, Massachusetts, United States of America
Sean Rollins, Daniel T. Leung, Richelle C. Charles, Regina C. LaRocque, Stephen B. Calderwood, Edward T. Ryan
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
David A. Sarracino, Bryan Krastins
Thermo Fisher Scientific, Cambridge, Massachusetts, United States of America
Stephen B. Calderwood
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Joshua LaBaer
Arizona State University, Tempe, Arizona, United States of America
Edward T. Ryan
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

Corresponding Author

Email: alaullah@icddrb.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS MP YH AR MSB SR DAS BK RCL SBC JBH JL FQ ETR. Performed the experiments: AS FK MAS TR MP YH AR MSB SR AK MA DTL BK RCC. Analyzed the data: AS FK MAS TR MP YH MSB DAS BK RCC SBC JBH JL FQ ETR. Contributed reagents/materials/analysis tools: AK MP YH BK DAS AC WAB JL. Wrote the paper: AS FK MAS TR MP YH AR MSB SR AK MA DTL DAS BK RCC RCL AC SBC WAB JBH JL FQ ETR.