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Research Article

The Diagnostic Sensitivity of Dengue Rapid Test Assays Is Significantly Enhanced by Using a Combined Antigen and Antibody Testing Approach

  • Scott R. Fry,

    Affiliation: Research and Development, Alere, Brisbane, Australia

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  • Michelle Meyer,

    Affiliation: Research and Development, Alere, Brisbane, Australia

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  • Matthew G. Semple,

    Affiliation: Research and Development, Alere, Brisbane, Australia

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  • Cameron P. Simmons,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Shamala Devi Sekaran,

    Affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

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  • Johnny X. Huang,

    Affiliation: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia

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  • Catriona McElnea,

    Affiliation: Research and Development, Alere, Brisbane, Australia

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  • Chang-Yi Huang,

    Affiliation: Research and Development, Alere, Brisbane, Australia

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  • Andrea Valks,

    Affiliation: Research and Development, Alere, Brisbane, Australia

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  • Paul R. Young,

    Affiliation: Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia

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  • Matthew A. Cooper mail

    m.cooper@imb.uq.edu.au

    Affiliation: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia

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  • Published: June 21, 2011
  • DOI: 10.1371/journal.pntd.0001199

About the Authors

Scott R. Fry, Michelle Meyer, Matthew G. Semple, Catriona McElnea, Chang-Yi Huang, Andrea Valks
Research and Development, Alere, Brisbane, Australia
Cameron P. Simmons
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Shamala Devi Sekaran
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Paul R. Young
Centre for Infectious Disease Research, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
Johnny X. Huang, Matthew A. Cooper
Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia

Corresponding Author

Email: m.cooper@imb.uq.edu.au

Competing Interests

SRF, MGS, MM, CM, C-YH and AV are employed by Alere, Australia. MAC was awarded an ARC Linkage Grant with Alere, Australia.

Author Contributions

Conceived and designed the experiments: SRF MM MGS CPS SDS JXH AV MAC. Performed the experiments: SRF MM MGS CPS SDS JXH. Analyzed the data: SRF MM MGS CPS SDS AV JXH MAC. Contributed reagents/materials/analysis tools: CPS SDS CM C-YH PRY MAC. Wrote the paper: SRF CPS SDS JXH AV PRY MAC.