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Research Article

TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia)

  • Asha Jayakumar,

    Affiliation: Yale University School of Public Health, New Haven, Connecticut, United States of America

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  • Tiago M. Castilho,

    Affiliation: Yale University School of Public Health, New Haven, Connecticut, United States of America

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  • Esther Park,

    Affiliation: Yale University School of Public Health, New Haven, Connecticut, United States of America

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  • Karen Goldsmith-Pestana,

    Affiliation: Yale University School of Public Health, New Haven, Connecticut, United States of America

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  • Jenefer M. Blackwell,

    Affiliation: Centre for Child Health Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, Australia

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  • Diane McMahon-Pratt mail

    diane.mcmahon-pratt@yale.edu

    Affiliation: Yale University School of Public Health, New Haven, Connecticut, United States of America

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  • Published: June 14, 2011
  • DOI: 10.1371/journal.pntd.0001204

About the Authors

Asha Jayakumar, Tiago M. Castilho, Esther Park, Karen Goldsmith-Pestana, Diane McMahon-Pratt
Yale University School of Public Health, New Haven, Connecticut, United States of America
Jenefer M. Blackwell
Centre for Child Health Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, Australia

Corresponding Author

Email: diane.mcmahon-pratt@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DMP AJ. Performed the experiments: TMC KGP EP AJ. Analyzed the data: AJ DMP JMB TMC. Contributed reagents/materials/analysis tools: JMB. Wrote the paper: JMB AJ DMP EP KGP TMC.