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Research Article

Emergence of a Globally Dominant IncHI1 Plasmid Type Associated with Multiple Drug Resistant Typhoid

  • Kathryn E. Holt equal contributor mail,

    equal contributor Contributed equally to this work with: Kathryn E. Holt, Minh Duy Phan

    kholt@unimelb.edu.au

    Affiliations: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia

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  • Minh Duy Phan equal contributor,

    equal contributor Contributed equally to this work with: Kathryn E. Holt, Minh Duy Phan

    Affiliations: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia

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  • Stephen Baker,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Pham Thanh Duy,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Tran Vu Thieu Nga,

    Affiliation: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Satheesh Nair,

    Affiliation: Laboratory of Enteric Pathogens, Health Protection Agency, Colindale, United Kingdom

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  • A. Keith Turner,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Ciara Walsh,

    Affiliation: Food Safety Authority of Ireland, Dublin, Ireland

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  • Séamus Fanning,

    Affiliation: School of Public Health, Physiotherapy and Population Science, UCD Centre for Food Safety, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin, Ireland

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  • Sinéad Farrell-Ward,

    Affiliation: School of Public Health, Physiotherapy and Population Science, UCD Centre for Food Safety, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin, Ireland

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  • Shanta Dutta,

    Affiliation: National Institute of Cholera and Enteric Diseases, Kolkata, India

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  • Sam Kariuki,

    Affiliation: Kenya Medical Research Institute, Nairobi, Kenya

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  • François-Xavier Weill,

    Affiliation: Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Paris, France

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  • Julian Parkhill,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Gordon Dougan,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • John Wain

    Affiliation: Laboratory of Enteric Pathogens, Health Protection Agency, Colindale, United Kingdom

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  • Published: July 19, 2011
  • DOI: 10.1371/journal.pntd.0001245

About the Authors

Kathryn E. Holt, Minh Duy Phan, A. Keith Turner, Julian Parkhill, Gordon Dougan
Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
Kathryn E. Holt
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia
Minh Duy Phan
School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia
Stephen Baker, Pham Thanh Duy, Tran Vu Thieu Nga
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Satheesh Nair, John Wain
Laboratory of Enteric Pathogens, Health Protection Agency, Colindale, United Kingdom
Ciara Walsh
Food Safety Authority of Ireland, Dublin, Ireland
Séamus Fanning, Sinéad Farrell-Ward
School of Public Health, Physiotherapy and Population Science, UCD Centre for Food Safety, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin, Ireland
Shanta Dutta
National Institute of Cholera and Enteric Diseases, Kolkata, India
Sam Kariuki
Kenya Medical Research Institute, Nairobi, Kenya
François-Xavier Weill
Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Paris, France

Corresponding Author

Email: kholt@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KEH MDP JP GD JW. Performed the experiments: MDP SB PTD TVTN SN AKT CW SF SFW SD SK FXW. Analyzed the data: KEH MDP SB. Contributed reagents/materials/analysis tools: CW SF SFW SD SK FXW. Wrote the paper: KEH MDP GD JW.