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Research Article

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

  • Geraldine De Muylder mail,

    Geraldine.DeMuylder@ucsf.edu

    Affiliation: Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Kenny K. H. Ang,

    Affiliation: Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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  • Steven Chen,

    Affiliation: Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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  • Michelle R. Arkin,

    Affiliation: Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

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  • Juan C. Engel,

    Affiliation: Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • James H. McKerrow

    Affiliation: Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

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  • Published: July 19, 2011
  • DOI: 10.1371/journal.pntd.0001253

About the Authors

Geraldine De Muylder, Juan C. Engel, James H. McKerrow
Department of Pathology, Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America
Kenny K. H. Ang, Steven Chen, Michelle R. Arkin
Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: Geraldine.DeMuylder@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GDM JCE JHM. Performed the experiments: GDM KKHA SC. Analyzed the data: GDM KKHA SC JCE JHM. Contributed reagents/materials/analysis tools: MRA. Wrote the paper: GDM JCE MRA JHM.