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Research Article

A Multi-Center Randomized Trial to Assess the Efficacy of Gatifloxacin versus Ciprofloxacin for the Treatment of Shigellosis in Vietnamese Children

  • Ha Vinh,

    Affiliations: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Vo Thi Cuc Anh,

    Affiliation: Huu Nghi Hospital, Cao Lanh, Dong Thap Province, Vietnam

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  • Nguyen Duc Anh,

    Affiliation: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • James I. Campbell,

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Nguyen Van Minh Hoang,

    Affiliations: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Tran Vu Thieu Nga,

    Affiliation: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Nguyen Thi Khanh Nhu,

    Affiliation: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Pham Van Minh,

    Affiliations: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Cao Thu Thuy,

    Affiliations: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Pham Thanh Duy,

    Affiliation: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

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  • Le Thi Phuong,

    Affiliation: Huu Nghi Hospital, Cao Lanh, Dong Thap Province, Vietnam

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  • Ha Thi Loan,

    Affiliation: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Mai Thu Chinh,

    Affiliation: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Nguyen Thi Thu Thao,

    Affiliation: School of Medicine and Pharmacy, Ho Chi Minh City, Vietnam

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  • Nguyen Thi Hong Tham,

    Affiliation: Huu Nghi Hospital, Cao Lanh, Dong Thap Province, Vietnam

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  • Bui Li Mong,

    Affiliation: Huu Nghi Hospital, Cao Lanh, Dong Thap Province, Vietnam

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  • Phan Van Be Bay,

    Affiliation: Huu Nghi Hospital, Cao Lanh, Dong Thap Province, Vietnam

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  • Jeremy N. Day,

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Christiane Dolecek,

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Nguyen Phu Huong Lan,

    Affiliation: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • To Song Diep,

    Affiliation: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Jeremy J. Farrar,

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Nguyen Van Vinh Chau,

    Affiliation: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

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  • Marcel Wolbers,

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Stephen Baker mail

    sbaker@oucru.org

    Affiliations: The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Published: August 02, 2011
  • DOI: 10.1371/journal.pntd.0001264

About the Authors

Ha Vinh, Nguyen Van Minh Hoang, Pham Van Minh, Cao Thu Thuy, Ha Thi Loan, Mai Thu Chinh, Nguyen Phu Huong Lan, To Song Diep, Nguyen Van Vinh Chau
The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Ha Vinh, Nguyen Duc Anh, James I. Campbell, Nguyen Van Minh Hoang, Tran Vu Thieu Nga, Nguyen Thi Khanh Nhu, Pham Van Minh, Cao Thu Thuy, Pham Thanh Duy, Jeremy N. Day, Christiane Dolecek, Jeremy J. Farrar, Marcel Wolbers, Stephen Baker
The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
Vo Thi Cuc Anh, Le Thi Phuong, Nguyen Thi Hong Tham, Bui Li Mong, Phan Van Be Bay
Huu Nghi Hospital, Cao Lanh, Dong Thap Province, Vietnam
James I. Campbell, Jeremy N. Day, Christiane Dolecek, Jeremy J. Farrar, Marcel Wolbers, Stephen Baker
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom
Nguyen Thi Thu Thao
School of Medicine and Pharmacy, Ho Chi Minh City, Vietnam

Corresponding Author

Email: sbaker@oucru.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HV CD JJF NVVC SB. Performed the experiments: HV VTCA JIC NVMH TVTN NTKN PVM CTT PTD LTP HTL MTC NGTTT NTHT BLM PVBB NPHL TSD. Analyzed the data: NDA TVTN MW SB. Contributed reagents/materials/analysis tools: JND. Wrote the paper: HV MW SB.