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Research Article

Chagasic Thymic Atrophy Does Not Affect Negative Selection but Results in the Export of Activated CD4+CD8+ T Cells in Severe Forms of Human Disease

  • Alexandre Morrot mail,

    morrot@micro.ufrj.br

    Affiliations: Department of Immunology, Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Eugênia Terra-Granado,

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Ana Rosa Pérez,

    Affiliation: Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Argentina

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  • Suse Dayse Silva-Barbosa,

    Affiliations: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Department of Clinical Research, National Cancer Institute, Rio de Janeiro, Brazil

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  • Novica M. Milićević,

    Affiliation: Institute of Histology and Embryology, Faculty of Medicine, University of Beograd, Beograd, Serbia

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  • Désio Aurélio Farias-de-Oliveira,

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Luiz Ricardo Berbert,

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Juliana De Meis,

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Christina Maeda Takiya,

    Affiliation: Biomedical Science Institute, Cell Pathology Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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  • Juan Beloscar,

    Affiliation: Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Argentina

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  • Xiaoping Wang,

    Affiliation: Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

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  • Vivian Kont,

    Affiliation: Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

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  • Pärt Peterson,

    Affiliation: Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

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  • Oscar Bottasso,

    Affiliation: Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Argentina

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  • Wilson Savino

    Affiliation: Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

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  • Published: August 16, 2011
  • DOI: 10.1371/journal.pntd.0001268

About the Authors

Alexandre Morrot
Department of Immunology, Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Alexandre Morrot, Eugênia Terra-Granado, Suse Dayse Silva-Barbosa, Désio Aurélio Farias-de-Oliveira, Luiz Ricardo Berbert, Juliana De Meis, Wilson Savino
Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Ana Rosa Pérez, Juan Beloscar, Oscar Bottasso
Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Argentina
Suse Dayse Silva-Barbosa
Department of Clinical Research, National Cancer Institute, Rio de Janeiro, Brazil
Novica M. Milićević
Institute of Histology and Embryology, Faculty of Medicine, University of Beograd, Beograd, Serbia
Christina Maeda Takiya
Biomedical Science Institute, Cell Pathology Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Xiaoping Wang, Vivian Kont, Pärt Peterson
Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia

Corresponding Author

Email: morrot@micro.ufrj.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AM. Performed the experiments: AM ETG ARP SDSB NMM DAFDO LRB CMT JB XW. Analyzed the data: AM ETG ARP SDSB AMM JDM PP OB WS. Contributed reagents/materials/analysis tools: ARP CMT VK PP WS. Wrote the paper: AM.