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Research Article

A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus

  • Yoshimi Tsuda,

    Affiliation: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Patrizia Caposio,

    Affiliation: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Christopher J. Parkins,

    Affiliation: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Sara Botto,

    Affiliation: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Ilhem Messaoudi,

    Affiliation: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Luka Cicin-Sain,

    Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Heinz Feldmann,

    Affiliation: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Michael A. Jarvis mail

    jarvismi@ohsu.edu

    Affiliations: Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Published: August 09, 2011
  • DOI: 10.1371/journal.pntd.0001275

About the Authors

Yoshimi Tsuda, Heinz Feldmann
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
Patrizia Caposio, Christopher J. Parkins, Sara Botto, Ilhem Messaoudi, Michael A. Jarvis
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America
Luka Cicin-Sain
Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
Michael A. Jarvis
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

Corresponding Author

Email: jarvismi@ohsu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAJ HF YT. Performed the experiments: YT HF PC CJP SB MAJ. Analyzed the data: MAJ HF YT. Wrote the paper: MAJ HF. Involved in planning the immunological aspects of the study: IM LC-S MAJ.