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Research Article

Inflammatory Cytokine Expression Is Associated with Chikungunya Virus Resolution and Symptom Severity

  • Alyson A. Kelvin mail,

    akelvin@sardiniaresearchanddevelopment.com

    Affiliations: Sardinia Research and Development (SaRD), University di Sassari, Sassari, Italy, Immune Diagnostics and Research (IDR), Toronto Medical Discovery Tower (TDMT), Toronto, Ontario, Canada

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  • David Banner,

    Affiliation: Experimental Therapeutics, University Health Network (UHN), Toronto, Ontario, Canada

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  • Giuliano Silvi,

    Affiliation: Dipartimento di Sanità Pubblica, Azienda Usl di Ravenna, Ferrara, Italy

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  • Maria Luisa Moro,

    Affiliation: Agenzia Sanitaria e Sociale Regione Emilia-Romagna, Bologna, Italy

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  • Nadir Spataro,

    Affiliation: Department of Hematology and Oncology, Alma Mater Studiorum - University of Bologna, Bologna, Italy

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  • Paolo Gaibani,

    Affiliation: Department of Hematology and Oncology, Alma Mater Studiorum - University of Bologna, Bologna, Italy

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  • Francesca Cavrini,

    Affiliation: Department of Hematology and Oncology, Alma Mater Studiorum - University of Bologna, Bologna, Italy

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  • Anna Pierro,

    Affiliation: Department of Hematology and Oncology, Alma Mater Studiorum - University of Bologna, Bologna, Italy

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  • Giada Rossini,

    Affiliation: Department of Hematology and Oncology, Alma Mater Studiorum - University of Bologna, Bologna, Italy

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  • Mark J. Cameron,

    Affiliation: Experimental Therapeutics, University Health Network (UHN), Toronto, Ontario, Canada

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  • Jesus F. Bermejo-Martin,

    Affiliations: National Centre of Influenza, Hospital Clínico Universitario de Valladolid, Valladolid, Spain, Unidad de Investigación en Infección e Inmunidad - Microbiology Service, Hospital Clínico Universitario de Valladolid - Instituto de Estudios de Ciencias de la Salud de Castilla y León (IECSCYL), Valladolid, Spain

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  • Stéphane G. Paquette,

    Affiliations: Experimental Therapeutics, University Health Network (UHN), Toronto, Ontario, Canada, Faculty of Medicine, Institute of Medical Science (IMS), University of Toronto, Toronto, Ontario, Canada

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  • Luoling Xu,

    Affiliation: Experimental Therapeutics, University Health Network (UHN), Toronto, Ontario, Canada

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  • Ali Danesh,

    Affiliation: Experimental Therapeutics, University Health Network (UHN), Toronto, Ontario, Canada

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  • Amber Farooqui,

    Affiliation: Sardinia Research and Development (SaRD), University di Sassari, Sassari, Italy

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  • Ilaria Borghetto,

    Affiliations: Sardinia Research and Development (SaRD), University di Sassari, Sassari, Italy, Dipartimento di Scienze Biomediche, University di Sassari, Sassari, Italy

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  • David J. Kelvin,

    Affiliations: Experimental Therapeutics, University Health Network (UHN), Toronto, Ontario, Canada, Faculty of Medicine, Institute of Medical Science (IMS), University of Toronto, Toronto, Ontario, Canada, PhD School in Biomolecular and Biotechnology Sciences, University of Sassari, Sassari, Italy

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  • Vittorio Sambri,

    Affiliation: Department of Hematology and Oncology, Alma Mater Studiorum - University of Bologna, Bologna, Italy

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  • Salvatore Rubino

    Affiliations: Sardinia Research and Development (SaRD), University di Sassari, Sassari, Italy, Dipartimento di Scienze Biomediche, University di Sassari, Sassari, Italy

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  • Published: August 16, 2011
  • DOI: 10.1371/journal.pntd.0001279

About the Authors

Alyson A. Kelvin, Amber Farooqui, Ilaria Borghetto, Salvatore Rubino
Sardinia Research and Development (SaRD), University di Sassari, Sassari, Italy
Alyson A. Kelvin
Immune Diagnostics and Research (IDR), Toronto Medical Discovery Tower (TDMT), Toronto, Ontario, Canada
David Banner, Mark J. Cameron, Stéphane G. Paquette, Luoling Xu, Ali Danesh, David J. Kelvin
Experimental Therapeutics, University Health Network (UHN), Toronto, Ontario, Canada
Giuliano Silvi
Dipartimento di Sanità Pubblica, Azienda Usl di Ravenna, Ferrara, Italy
Maria Luisa Moro
Agenzia Sanitaria e Sociale Regione Emilia-Romagna, Bologna, Italy
Nadir Spataro, Paolo Gaibani, Francesca Cavrini, Anna Pierro, Giada Rossini, Vittorio Sambri
Department of Hematology and Oncology, Alma Mater Studiorum - University of Bologna, Bologna, Italy
Jesus F. Bermejo-Martin
National Centre of Influenza, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
Jesus F. Bermejo-Martin
Unidad de Investigación en Infección e Inmunidad - Microbiology Service, Hospital Clínico Universitario de Valladolid - Instituto de Estudios de Ciencias de la Salud de Castilla y León (IECSCYL), Valladolid, Spain
Stéphane G. Paquette, David J. Kelvin
Faculty of Medicine, Institute of Medical Science (IMS), University of Toronto, Toronto, Ontario, Canada
Ilaria Borghetto, Salvatore Rubino
Dipartimento di Scienze Biomediche, University di Sassari, Sassari, Italy
David J. Kelvin
PhD School in Biomolecular and Biotechnology Sciences, University of Sassari, Sassari, Italy

Corresponding Author

Email: akelvin@sardiniaresearchanddevelopment.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AAK DB DJK VS SR. Performed the experiments: DB SGP LX AD AF IB. Analyzed the data: AAK MJC JFB-M. Contributed reagents/materials/analysis tools: GS MLM NS PG FC AP GR DJK VS SR. Wrote the paper: AAK.