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Research Article

In Silico Analysis of Six Known Leishmania major Antigens and In Vitro Evaluation of Specific Epitopes Eliciting HLA-A2 Restricted CD8 T Cell Response

  • Negar Seyed,

    Affiliation: Molecular Immunology and Vaccine Research Lab, Pasteur Institute of Iran, Tehran, Iran

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  • Farnaz Zahedifard,

    Affiliation: Molecular Immunology and Vaccine Research Lab, Pasteur Institute of Iran, Tehran, Iran

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  • Shima Safaiyan,

    Affiliation: Molecular Immunology and Vaccine Research Lab, Pasteur Institute of Iran, Tehran, Iran

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  • Elham Gholami,

    Affiliation: Molecular Immunology and Vaccine Research Lab, Pasteur Institute of Iran, Tehran, Iran

    X
  • Fatemeh Doustdari,

    Affiliation: Molecular Immunology and Vaccine Research Lab, Pasteur Institute of Iran, Tehran, Iran

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  • Kayhan Azadmanesh,

    Affiliation: Department of Virology, Pasteur Institute of Iran, Tehran, Iran

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  • Maryam Mirzaei,

    Affiliation: Health Care Center, Chaheshk, Mashhad, Iran

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  • Nasir Saeedi Eslami,

    Affiliation: National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran

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  • Akbar Khadem Sadegh,

    Affiliation: Department of Electron Microscopy and Clinical Research, Pasteur Institute of Iran, Tehran, Iran

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  • Ali Eslami far,

    Affiliation: Department of Electron Microscopy and Clinical Research, Pasteur Institute of Iran, Tehran, Iran

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  • Iraj Sharifi,

    Affiliation: School of Medicine, Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran

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  • Sima Rafati mail

    sima-rafatisy@pasteur.ac.ir

    Affiliation: Molecular Immunology and Vaccine Research Lab, Pasteur Institute of Iran, Tehran, Iran

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  • Published: September 06, 2011
  • DOI: 10.1371/journal.pntd.0001295

About the Authors

Negar Seyed, Farnaz Zahedifard, Shima Safaiyan, Elham Gholami, Fatemeh Doustdari, Sima Rafati
Molecular Immunology and Vaccine Research Lab, Pasteur Institute of Iran, Tehran, Iran
Kayhan Azadmanesh
Department of Virology, Pasteur Institute of Iran, Tehran, Iran
Maryam Mirzaei
Health Care Center, Chaheshk, Mashhad, Iran
Nasir Saeedi Eslami
National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
Akbar Khadem Sadegh, Ali Eslami far
Department of Electron Microscopy and Clinical Research, Pasteur Institute of Iran, Tehran, Iran
Iraj Sharifi
School of Medicine, Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran

Corresponding Author

Email: sima-rafatisy@pasteur.ac.ir

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SR NS IS. Performed the experiments: NS FZ SS EG FD MM NSE AKS. Analyzed the data: NS SR KA. Contributed reagents/materials/analysis tools: AEf. Wrote the paper: NS SR.