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Research Article

Serum Metabolomics Reveals Higher Levels of Polyunsaturated Fatty Acids in Lepromatous Leprosy: Potential Markers for Susceptibility and Pathogenesis

  • Reem Al-Mubarak,

    Affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Jason Vander Heiden,

    Affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Corey D. Broeckling,

    Affiliation: Proteomics and Metabolomics Facility, Colorado State University, Fort Collins, Colorado, United States of America

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  • Marivic Balagon,

    Affiliation: Leonard Wood Memorial Center for Leprosy Research, Cebu, Philippines

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  • Patrick J. Brennan,

    Affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Varalakshmi D. Vissa mail

    vvissa@colostate.edu

    Affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Published: September 06, 2011
  • DOI: 10.1371/journal.pntd.0001303

About the Authors

Reem Al-Mubarak, Jason Vander Heiden, Patrick J. Brennan, Varalakshmi D. Vissa
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
Corey D. Broeckling
Proteomics and Metabolomics Facility, Colorado State University, Fort Collins, Colorado, United States of America
Marivic Balagon
Leonard Wood Memorial Center for Leprosy Research, Cebu, Philippines

Corresponding Author

Email: vvissa@colostate.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RA-M VDV. Performed the experiments: RA-M CDB. Analyzed the data: RA-M JVH CDB VDV. Contributed reagents/materials/analysis tools: MB VDV. Wrote the paper: RA-M JVH PJB VDV.