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Research Article

Effective Oral Favipiravir (T-705) Therapy Initiated after the Onset of Clinical Disease in a Model of Arenavirus Hemorrhagic Fever

  • Michelle Mendenhall,

    Affiliation: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America

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  • Andrew Russell,

    Affiliation: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America

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  • Donald F. Smee,

    Affiliation: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America

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  • Jeffery O. Hall,

    Affiliation: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America

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  • Ramona Skirpstunas,

    Affiliations: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America, Department of Agriculture and Food, State of Utah, Logan, Utah, United States of America

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  • Yousuke Furuta,

    Affiliation: Research Laboratories, Toyama Chemical Company, Ltd., Toyama, Japan

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  • Brian B. Gowen mail

    brian.gowen@usu.edu

    Affiliation: Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America

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  • Published: October 11, 2011
  • DOI: 10.1371/journal.pntd.0001342

About the Authors

Michelle Mendenhall, Andrew Russell, Donald F. Smee, Jeffery O. Hall, Ramona Skirpstunas, Brian B. Gowen
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
Ramona Skirpstunas
Department of Agriculture and Food, State of Utah, Logan, Utah, United States of America
Yousuke Furuta
Research Laboratories, Toyama Chemical Company, Ltd., Toyama, Japan

Corresponding Author

Email: brian.gowen@usu.edu

Competing Interests

YF is employed by the Toyama Chemical Co., Ltd., the manufacturer of favipiravir.

Author Contributions

Conceived and designed the experiments: BBG JOH YF. Performed the experiments: MM AR BBG. Analyzed the data: BBG MM DFS JOH RS YF. Contributed reagents/materials/analysis tools: YF DFS RS. Wrote the paper: MM BBG.