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Research Article

Crystal Structure of the Complex mAb 17.2 and the C-Terminal Region of Trypanosoma cruzi P2β Protein: Implications in Cross-Reactivity

  • Juan Carlos Pizarro,

    Affiliations: Unité d'Immunologie Structurale, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2185, Paris, France

    Current address: Structural Genomic Consortium (SGC), University of Toronto, Toronto, Canada

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  • Ginette Boulot,

    Affiliations: Unité d'Immunologie Structurale, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2185, Paris, France

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  • Graham A. Bentley,

    Affiliations: Unité d'Immunologie Structurale, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2185, Paris, France

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  • Karina A. Gómez,

    Affiliation: Laboratorio de Biología Molecular de la Enfermedad de Chagas, INGEBI-CONICET, Buenos Aires, Argentina

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  • Johan Hoebeke,

    Affiliation: UPR9021 du CNRS, Strasbourg, France

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  • Mireille Hontebeyrie,

    Affiliation: Institut Pasteur, Paris, France

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  • Mariano J. Levin,

    Affiliation: Laboratorio de Biología Molecular de la Enfermedad de Chagas, INGEBI-CONICET, Buenos Aires, Argentina

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  • Cristian R. Smulski mail

    c.smulski@unistra.fr

    Affiliations: Laboratorio de Biología Molecular de la Enfermedad de Chagas, INGEBI-CONICET, Buenos Aires, Argentina, UPR9021 du CNRS, Strasbourg, France

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  • Published: November 01, 2011
  • DOI: 10.1371/journal.pntd.0001375

About the Authors

Juan Carlos Pizarro, Ginette Boulot, Graham A. Bentley
Unité d'Immunologie Structurale, Institut Pasteur, Paris, France
Juan Carlos Pizarro, Ginette Boulot, Graham A. Bentley
Centre National de la Recherche Scientifique, Unité de Recherche Associée 2185, Paris, France
Karina A. Gómez, Mariano J. Levin, Cristian R. Smulski
Laboratorio de Biología Molecular de la Enfermedad de Chagas, INGEBI-CONICET, Buenos Aires, Argentina
Johan Hoebeke, Cristian R. Smulski
UPR9021 du CNRS, Strasbourg, France
Mireille Hontebeyrie
Institut Pasteur, Paris, France

Corresponding Author

Email: c.smulski@unistra.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GAB MJL MH CRS. Performed the experiments: JCP GB GAB KAG MH CRS. Analyzed the data: JCP GAB KAG JH CRS. Contributed reagents/materials/analysis tools: KAG MJL MH GAB CRS. Wrote the paper: JCP GAB MH CRS.