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Research Article

Ebola Virus Glycoprotein Needs an Additional Trigger, beyond Proteolytic Priming for Membrane Fusion

  • Shridhar Bale,

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Tong Liu,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Sheng Li,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Yuhao Wang,

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Dafna Abelson,

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Marnie Fusco,

    Affiliation: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Virgil L. Woods Jr. mail,

    vwoods@ucsd.edu (VLW); erica@scripps.edu (EOS)

    Affiliation: Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Erica Ollmann Saphire mail

    vwoods@ucsd.edu (VLW); erica@scripps.edu (EOS)

    Affiliations: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Published: November 15, 2011
  • DOI: 10.1371/journal.pntd.0001395

About the Authors

Shridhar Bale, Dafna Abelson, Marnie Fusco, Erica Ollmann Saphire
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
Tong Liu, Sheng Li, Yuhao Wang, Virgil L. Woods Jr.
Department of Medicine, University of California San Diego, La Jolla, California, United States of America
Erica Ollmann Saphire
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SB TL SL DA MF. Performed the experiments: SB TL SL DA MF. Analyzed the data: SB TL SL. Contributed reagents/materials/analysis tools: SB TL SL YW DA MF. Wrote the paper: SB TL VLW EOS.