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Research Article

Individuals with Le(a+b−) Blood Group Have Increased Susceptibility to Symptomatic Vibrio cholerae O1 Infection

  • Mohammad Arifuzzaman,

    Affiliations: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Tanvir Ahmed,

    Affiliation: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Mohammad Arif Rahman,

    Affiliation: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Fahima Chowdhury,

    Affiliation: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Rasheduzzaman Rashu,

    Affiliation: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Ashraful I. Khan,

    Affiliation: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Regina C. LaRocque,

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jason B. Harris,

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Taufiqur Rahman Bhuiyan,

    Affiliation: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Edward T. Ryan,

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Stephen B. Calderwood equal contributor,

    equal contributor Contributed equally to this work with: Stephen B. Calderwood, Firdausi Qadri

    Affiliations: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Firdausi Qadri equal contributor mail

    equal contributor Contributed equally to this work with: Stephen B. Calderwood, Firdausi Qadri

    fqadri@icddrb.org

    Affiliation: Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh

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  • Published: December 27, 2011
  • DOI: 10.1371/journal.pntd.0001413

About the Authors

Mohammad Arifuzzaman, Tanvir Ahmed, Mohammad Arif Rahman, Fahima Chowdhury, Rasheduzzaman Rashu, Ashraful I. Khan, Taufiqur Rahman Bhuiyan, Firdausi Qadri
Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR,B), Dhaka, Bangladesh
Mohammad Arifuzzaman, Regina C. LaRocque, Jason B. Harris, Edward T. Ryan, Stephen B. Calderwood
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Regina C. LaRocque, Edward T. Ryan, Stephen B. Calderwood
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
Jason B. Harris
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
Edward T. Ryan
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Stephen B. Calderwood
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: fqadri@icddrb.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FQ MA TA TRB JBH. Performed the experiments: MA MAR RR. Analyzed the data: MA MAR TA TRB FC AIK. Contributed reagents/materials/analysis tools: SBC ETR RCL FC. Wrote the paper: MA MAR ETR FQ SBC.