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Research Article

Knockout of the dhfr-ts Gene in Trypanosoma cruzi Generates Attenuated Parasites Able to Confer Protection against a Virulent Challenge

  • Cecilia Perez Brandan mail,

    cecilia.perezbrandan@conicet.gov.ar

    Affiliation: Instituto de Patologia Experimental - CONICET, Universidad Nacional de Salta, Salta, Argentina

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  • Angel M. Padilla,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

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  • Dan Xu,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

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  • Rick L. Tarleton,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

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  • Miguel A. Basombrio

    Affiliation: Instituto de Patologia Experimental - CONICET, Universidad Nacional de Salta, Salta, Argentina

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  • Published: December 13, 2011
  • DOI: 10.1371/journal.pntd.0001418

About the Authors

Cecilia Perez Brandan, Miguel A. Basombrio
Instituto de Patologia Experimental - CONICET, Universidad Nacional de Salta, Salta, Argentina
Angel M. Padilla, Dan Xu, Rick L. Tarleton
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

Corresponding Author

Email: cecilia.perezbrandan@conicet.gov.ar

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CPB AMP MAB RLT. Performed the experiments: CPB AMP DX. Analyzed the data: CPB AMP. Contributed reagents/materials/analysis tools: CPB AMP DX. Wrote the paper: CPB AMP.