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Research Article

Tissue Tropism and Target Cells of NSs-Deleted Rift Valley Fever Virus in Live Immunodeficient Mice

  • Céline Gommet,

    Affiliation: Central Animal Facilities, Institut Pasteur, Paris, France

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  • Agnès Billecocq,

    Affiliation: Molecular Genetics of Bunyaviruses, Institut Pasteur, Paris, France

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  • Grégory Jouvion,

    Affiliation: Human Histopathology and Animal Models, Institut Pasteur, Paris, France

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  • Milena Hasan,

    Affiliation: Center for Human Immunology, Institut Pasteur, Paris, France

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  • Tânia Zaverucha do Valle,

    Affiliations: Mouse Functional Genetics, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Paris, France

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  • Laurent Guillemot,

    Affiliations: Mouse Functional Genetics, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Paris, France

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  • Charlène Blanchet,

    Affiliation: Cytokines and Inflammation, Institut Pasteur, Paris, France

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  • Nico van Rooijen,

    Affiliation: Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands

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  • Xavier Montagutelli,

    Affiliations: Mouse Functional Genetics, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Paris, France

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  • Michèle Bouloy mail,

    panthier@pasteur.fr (JJP); mbouloy@pasteur.fr (MB)

    Affiliation: Molecular Genetics of Bunyaviruses, Institut Pasteur, Paris, France

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  • Jean-Jacques Panthier mail

    panthier@pasteur.fr (JJP); mbouloy@pasteur.fr (MB)

    Affiliations: Mouse Functional Genetics, Institut Pasteur, Paris, France, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Paris, France

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  • Published: December 06, 2011
  • DOI: 10.1371/journal.pntd.0001421

About the Authors

Céline Gommet
Central Animal Facilities, Institut Pasteur, Paris, France
Agnès Billecocq, Michèle Bouloy
Molecular Genetics of Bunyaviruses, Institut Pasteur, Paris, France
Grégory Jouvion
Human Histopathology and Animal Models, Institut Pasteur, Paris, France
Milena Hasan
Center for Human Immunology, Institut Pasteur, Paris, France
Tânia Zaverucha do Valle, Laurent Guillemot, Xavier Montagutelli, Jean-Jacques Panthier
Mouse Functional Genetics, Institut Pasteur, Paris, France
Tânia Zaverucha do Valle, Laurent Guillemot, Xavier Montagutelli, Jean-Jacques Panthier
Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Paris, France
Charlène Blanchet
Cytokines and Inflammation, Institut Pasteur, Paris, France
Nico van Rooijen
Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CG AB MH TZdV XM MB JJP. Performed the experiments: CG AB GJ MH TZdV LG CB. Analyzed the data: CG AB GJ MH CB TZdV XM MB JJP. Contributed reagents/materials/analysis tools: NvR. Wrote the paper: CG MB JJP.