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Research Article

A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans

  • Mariana L. Coutinho,

    Affiliations: Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America, Centro de Desenvolvimento Tecnologico, Universidade Federal de Pelotas, Pelotas, Brasil

    X
  • Henry A. Choy,

    Affiliations: Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America

    X
  • Melissa M. Kelley,

    Affiliation: Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America

    X
  • James Matsunaga,

    Affiliations: Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America

    X
  • Jane T. Babbitt,

    Affiliations: Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America

    X
  • Michael S. Lewis,

    Affiliation: Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America

    X
  • Jose Antonio G. Aleixo,

    Affiliation: Centro de Desenvolvimento Tecnologico, Universidade Federal de Pelotas, Pelotas, Brasil

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  • David A. Haake mail

    dhaake@ucla.edu

    Affiliations: Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California, United States of America

    X
  • Published: December 13, 2011
  • DOI: 10.1371/journal.pntd.0001422

About the Authors

Mariana L. Coutinho, Henry A. Choy, Melissa M. Kelley, James Matsunaga, Jane T. Babbitt, Michael S. Lewis, David A. Haake
Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
Mariana L. Coutinho, Jose Antonio G. Aleixo
Centro de Desenvolvimento Tecnologico, Universidade Federal de Pelotas, Pelotas, Brasil
Henry A. Choy, James Matsunaga, Jane T. Babbitt, David A. Haake
Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California, United States of America
David A. Haake
Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
David A. Haake
Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California, United States of America

Corresponding Author

Email: dhaake@ucla.edu

Competing Interests

The authors have read the journal's policy and have the following conflicts: Authors D.A.H. and J.M. are coinventors on United States Patent 7935357.

Author Contributions

Conceived and designed the experiments: MLC HAC JM DAH. Performed the experiments: MLC HAC MMK. Analyzed the data: MLC HAC JM MSL DAH. Contributed reagents/materials/analysis tools: HAC JM DAH. Wrote the paper: MLC HAC JM JTB JAGA DAH.