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Research Article

Analysis of Epitopes on Dengue Virus Envelope Protein Recognized by Monoclonal Antibodies and Polyclonal Human Sera by a High Throughput Assay

  • Hong-En Lin,

    Affiliation: Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Wen-Yang Tsai,

    Affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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  • I-Ju Liu,

    Affiliation: Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan

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  • Pi-Chun Li,

    Affiliation: Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan

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  • Mei-Ying Liao,

    Affiliation: Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan

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  • Jih-Jin Tsai,

    Affiliations: Tropical Medicine Center and Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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  • Yi-Chieh Wu,

    Affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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  • Chih-Yun Lai,

    Affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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  • Chih-Hsuan Lu,

    Affiliation: Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

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  • Jyh-Hsiung Huang,

    Affiliation: Department of Health, Center for Disease Control, Taipei, Taiwan

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  • Gwong-Jen Chang,

    Affiliation: Division of Vector-Borne Diseases, Department of Health and Human Service, Center for Disease Control and Prevention, Fort Collins, Colorado, United States of America

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  • Han-Chung Wu,

    Affiliation: Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan

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  • Wei-Kung Wang mail

    wangwk@hawaii.edu

    Affiliations: Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan, Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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  • Published: January 03, 2012
  • DOI: 10.1371/journal.pntd.0001447

About the Authors

Hong-En Lin, Chih-Hsuan Lu, Wei-Kung Wang
Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Wen-Yang Tsai, Yi-Chieh Wu, Chih-Yun Lai, Wei-Kung Wang
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America
I-Ju Liu, Pi-Chun Li, Mei-Ying Liao, Han-Chung Wu
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
Jih-Jin Tsai
Tropical Medicine Center and Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Jih-Jin Tsai
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Jyh-Hsiung Huang
Department of Health, Center for Disease Control, Taipei, Taiwan
Gwong-Jen Chang
Division of Vector-Borne Diseases, Department of Health and Human Service, Center for Disease Control and Prevention, Fort Collins, Colorado, United States of America

Corresponding Author

Email: wangwk@hawaii.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HEL WKW. Performed the experiments: HEL WYT IJL PCL MYL YCW CYL CHL. Analyzed the data: HEL WYT YCW WKW. Contributed reagents/materials/analysis tools: JJT JHH GJC HCW. Wrote the paper: HEL WKW.