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Research Article

A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni

  • Anna V. Protasio equal contributor,

    equal contributor Contributed equally to this work with: Anna V. Protasio, Isheng J. Tsai

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    X
  • Isheng J. Tsai equal contributor,

    equal contributor Contributed equally to this work with: Anna V. Protasio, Isheng J. Tsai

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    X
  • Anne Babbage,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    X
  • Sarah Nichol,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Martin Hunt,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Martin A. Aslett,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Nishadi De Silva,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    X
  • Giles S. Velarde,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Tim J. C. Anderson,

    Affiliation: Texas Biomedical Research Institute, San Antonio, Texas, United States of America

    X
  • Richard C. Clark,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    X
  • Claire Davidson,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Gary P. Dillon,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Nancy E. Holroyd,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Philip T. LoVerde,

    Affiliation: Departments of Biochemistry and Pathology, University of Texas Health Science Center, San Antonio, Texas, United States of America

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  • Christine Lloyd,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Jacquelline McQuillan,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    X
  • Guilherme Oliveira,

    Affiliations: Center for Excellence in Bioinformatics, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil, Genomics and Computational Biology Group, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil, National Institute for Science and Technology in Tropical Diseases, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil

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  • Thomas D. Otto,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Sophia J. Parker-Manuel,

    Affiliation: Department of Biology, University of York, Heslington, York, United Kingdom

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  • Michael A. Quail,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    X
  • R. Alan Wilson,

    Affiliation: Department of Biology, University of York, Heslington, York, United Kingdom

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  • Adhemar Zerlotini,

    Affiliation: Center for Excellence in Bioinformatics, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil

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  • David W. Dunne,

    Affiliation: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

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  • Matthew Berriman mail

    mb4@sanger.ac.uk

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

    X
  • Published: January 10, 2012
  • DOI: 10.1371/journal.pntd.0001455

About the Authors

Anna V. Protasio, Isheng J. Tsai, Anne Babbage, Sarah Nichol, Martin Hunt, Martin A. Aslett, Nishadi De Silva, Giles S. Velarde, Richard C. Clark, Claire Davidson, Gary P. Dillon, Nancy E. Holroyd, Christine Lloyd, Jacquelline McQuillan, Thomas D. Otto, Michael A. Quail, Matthew Berriman
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Tim J. C. Anderson
Texas Biomedical Research Institute, San Antonio, Texas, United States of America
Philip T. LoVerde
Departments of Biochemistry and Pathology, University of Texas Health Science Center, San Antonio, Texas, United States of America
Guilherme Oliveira, Adhemar Zerlotini
Center for Excellence in Bioinformatics, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
Guilherme Oliveira
Genomics and Computational Biology Group, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
Guilherme Oliveira
National Institute for Science and Technology in Tropical Diseases, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
Sophia J. Parker-Manuel, R. Alan Wilson
Department of Biology, University of York, Heslington, York, United Kingdom
David W. Dunne
Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: mb4@sanger.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MB. Performed the experiments: AVP AB. Analyzed the data: AVP IJT MH TDO. Contributed reagents/materials/analysis tools: CL TJCA SJPM RAW DWD PTL. Wrote the paper: AVP IJT MB. Data processing and loading GeneDB and SchistoDB: IJT NDS JM GO AZ MAA GSV. Manual genome improvement and curation of gene annotations: AVP IJT SN RCC CD GPD. Project management: NEH. Construction of sequencing libraries: MAQ.