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Research Article

Orientia tsutsugamushi in Human Scrub Typhus Eschars Shows Tropism for Dendritic Cells and Monocytes Rather than Endothelium

  • Daniel H. Paris mail,

    parigi@tropmedres.ac

    Affiliations: Mahidol-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Center for Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Headington, Oxford, United Kingdom

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  • Rattanaphone Phetsouvanh,

    Affiliation: Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao People's Democratic Republic

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  • Ampai Tanganuchitcharnchai,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Margaret Jones,

    Affiliation: Nuffield Department of Clinical Laboratory Sciences, Oxford University, Oxford, United Kingdom

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  • Kemajittra Jenjaroen,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Manivanh Vongsouvath,

    Affiliation: Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao People's Democratic Republic

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  • David P. J. Ferguson,

    Affiliation: Nuffield Department of Clinical Laboratory Sciences, Oxford University, Oxford, United Kingdom

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  • Stuart D. Blacksell,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Center for Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Headington, Oxford, United Kingdom

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  • Paul N. Newton,

    Affiliations: Center for Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Headington, Oxford, United Kingdom, Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao People's Democratic Republic

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  • Nicholas P. J. Day,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Center for Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Headington, Oxford, United Kingdom

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  • Gareth D. H. Turner

    Affiliations: Mahidol-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Center for Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Headington, Oxford, United Kingdom

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  • Published: January 10, 2012
  • DOI: 10.1371/journal.pntd.0001466

About the Authors

Daniel H. Paris, Ampai Tanganuchitcharnchai, Kemajittra Jenjaroen, Stuart D. Blacksell, Nicholas P. J. Day, Gareth D. H. Turner
Mahidol-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Daniel H. Paris, Stuart D. Blacksell, Paul N. Newton, Nicholas P. J. Day, Gareth D. H. Turner
Center for Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Headington, Oxford, United Kingdom
Rattanaphone Phetsouvanh, Manivanh Vongsouvath, Paul N. Newton
Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao People's Democratic Republic
Margaret Jones, David P. J. Ferguson
Nuffield Department of Clinical Laboratory Sciences, Oxford University, Oxford, United Kingdom

Corresponding Author

Email: parigi@tropmedres.ac

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DHP PNN NPJD GDHT. Performed the experiments: DHP AT MJ KJ. Analyzed the data: DHP DPJF SDB GDHT. Contributed reagents/materials/analysis tools: RP MV MJ SDB DPJF PNN. Wrote the paper: DHP GDHT NPJD.