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Research Article

Impact of Continuous Axenic Cultivation in Leishmania infantum Virulence

  • Diana Moreira equal contributor,

    equal contributor Contributed equally to this work with: Diana Moreira, Nuno Santarém

    Affiliation: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

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  • Nuno Santarém equal contributor,

    equal contributor Contributed equally to this work with: Diana Moreira, Nuno Santarém

    Affiliation: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

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  • Inês Loureiro,

    Affiliation: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

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  • Joana Tavares,

    Affiliations: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal

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  • Ana Marta Silva,

    Affiliation: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

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  • Ana Marina Amorim,

    Affiliation: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

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  • Ali Ouaissi,

    Affiliations: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, INSERM, UMR, CNRS 5235, Université Montpellier II, Montpellier, France

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  • Anabela Cordeiro-da-Silva ,

    Affiliations: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal

    These authors also contributed equally to this work.

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  • Ricardo Silvestre mail

    rleal@ibmc.up.pt

    Affiliation: Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

    These authors also contributed equally to this work.

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  • Published: January 24, 2012
  • DOI: 10.1371/journal.pntd.0001469

About the Authors

Diana Moreira, Nuno Santarém, Inês Loureiro, Joana Tavares, Ana Marta Silva, Ana Marina Amorim, Ali Ouaissi, Anabela Cordeiro-da-Silva, Ricardo Silvestre
Parasite Disease Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
Joana Tavares, Anabela Cordeiro-da-Silva
Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
Ali Ouaissi
INSERM, UMR, CNRS 5235, Université Montpellier II, Montpellier, France

Corresponding Author

Email: rleal@ibmc.up.pt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NS RS. Performed the experiments: DM NS AMA RS. Analyzed the data: DM NS AO RS ACdS. Contributed reagents/materials/analysis tools: IL JT AMS. Wrote the paper: DM NS RS.