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Research Article

A “Genome-to-Lead” Approach for Insecticide Discovery: Pharmacological Characterization and Screening of Aedes aegypti D1-like Dopamine Receptors

  • Jason M. Meyer equal contributor,

    equal contributor Contributed equally to this work with: Jason M. Meyer, Karin F. K. Ejendal

    Affiliation: Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America

    X
  • Karin F. K. Ejendal equal contributor,

    equal contributor Contributed equally to this work with: Jason M. Meyer, Karin F. K. Ejendal

    Affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America

    X
  • Larisa V. Avramova,

    Affiliation: Integrated Screening Technologies, Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana, United States of America

    X
  • Elisabeth E. Garland-Kuntz,

    Affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America

    X
  • Gloria I. Giraldo-Calderón,

    Affiliation: Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America

    X
  • Tarsis F. Brust,

    Affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America

    X
  • Val J. Watts,

    Affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America

    X
  • Catherine A. Hill mail

    hillca@purdue.edu

    Affiliation: Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America

    X
  • Published: January 24, 2012
  • DOI: 10.1371/journal.pntd.0001478

About the Authors

Jason M. Meyer, Gloria I. Giraldo-Calderón, Catherine A. Hill
Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America
Karin F. K. Ejendal, Elisabeth E. Garland-Kuntz, Tarsis F. Brust, Val J. Watts
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America
Larisa V. Avramova
Integrated Screening Technologies, Bindley Bioscience Center, Discovery Park, Purdue University, West Lafayette, Indiana, United States of America

Corresponding Author

Email: hillca@purdue.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMM KFKE VJW CAH. Performed the experiments: JMM KFKE LVA EEG-K GIG-C TFB. Analyzed the data: JMM KFKE LVA EEG-K GIG-C TFB VJW CAH. Contributed reagents/materials/analysis tools: VJW CAH. Wrote the paper: JMM KFKE VJW CAH.