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Research Article

Development and Characterization of a Reverse Genetic System for Studying Dengue Virus Serotype 3 Strain Variation and Neutralization

  • William B. Messer,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Boyd Yount,

    Affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Kari E. Hacker,

    Affiliation: Department of Microbiology and Immunology, and Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Eric F. Donaldson,

    Affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Jeremy P. Huynh,

    Affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Aravinda M. de Silva mail,

    aravinda_desilva@med.unc.edu (AMdS); rbaric@email.unc.edu (RSB)

    Affiliation: Department of Microbiology and Immunology, and Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Ralph S. Baric mail

    aravinda_desilva@med.unc.edu (AMdS); rbaric@email.unc.edu (RSB)

    Affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Published: February 28, 2012
  • DOI: 10.1371/journal.pntd.0001486

About the Authors

William B. Messer
Division of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
Boyd Yount, Eric F. Donaldson, Jeremy P. Huynh, Ralph S. Baric
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
Kari E. Hacker, Aravinda M. de Silva
Department of Microbiology and Immunology, and Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WBM BY KEH EFD AMdS RSB. Performed the experiments: WBM BY KEH JPH. Analyzed the data: WBM AMdS RSB. Contributed reagents/materials/analysis tools: WBM EFD BY KEH. Wrote the paper: WBM BY KEH EFD AMdS RSB.