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Research Article

Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background

  • Saskia Decuypere,

    Affiliations: Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom, Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

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  • Manu Vanaerschot,

    Affiliation: Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium

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  • Kirstyn Brunker,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom

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  • Hideo Imamura,

    Affiliations: Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, England, United Kingdom

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  • Sylke Müller,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

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  • Basudha Khanal,

    Affiliation: B.P. Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

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  • Suman Rijal,

    Affiliation: B.P. Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

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  • Jean-Claude Dujardin mail,

    jcdujardin@itg.be

    Affiliations: Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

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  • Graham H. Coombs

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom

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  • Published: February 28, 2012
  • DOI: 10.1371/journal.pntd.0001514

About the Authors

Saskia Decuypere, Manu Vanaerschot, Hideo Imamura, Jean-Claude Dujardin
Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
Saskia Decuypere, Kirstyn Brunker, Graham H. Coombs
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom
Saskia Decuypere, Sylke Müller
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
Hideo Imamura
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, England, United Kingdom
Basudha Khanal, Suman Rijal
B.P. Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal
Jean-Claude Dujardin
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

Corresponding Author

Email: jcdujardin@itg.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SD SM JCD GHC. Performed the experiments: SD MV KB. Analyzed the data: SD HI MV. Contributed reagents/materials/analysis tools: SR SM BK. Wrote the paper: SD GHC SM MV JCD.