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Research Article

Chemotactic and Inflammatory Responses in the Liver and Brain Are Associated with Pathogenesis of Rift Valley Fever Virus Infection in the Mouse

  • Kimberly K. Gray equal contributor,

    equal contributor Contributed equally to this work with: Kimberly K. Gray, Melissa N. Worthy

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Melissa N. Worthy equal contributor,

    equal contributor Contributed equally to this work with: Kimberly K. Gray, Melissa N. Worthy

    Affiliations: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Terry L. Juelich,

    Affiliation: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Stacy L. Agar,

    Affiliation: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America

    X
  • Allison Poussard,

    Affiliations: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Dan Ragland,

    Affiliation: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America

    X
  • Alexander N. Freiberg,

    Affiliations: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Tropical Diseases, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Michael R. Holbrook mail

    Michael.holbrook@nih.gov

    Affiliations: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America, Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Tropical Diseases, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Published: February 28, 2012
  • DOI: 10.1371/journal.pntd.0001529

About the Authors

Kimberly K. Gray, Michael R. Holbrook
Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
Melissa N. Worthy, Terry L. Juelich, Allison Poussard, Alexander N. Freiberg, Michael R. Holbrook
Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America
Melissa N. Worthy, Allison Poussard, Alexander N. Freiberg, Michael R. Holbrook
Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America
Stacy L. Agar, Dan Ragland, Michael R. Holbrook
Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America
Alexander N. Freiberg, Michael R. Holbrook
Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, Texas, United States of America
Alexander N. Freiberg, Michael R. Holbrook
Center for Tropical Diseases, The University of Texas Medical Branch, Galveston, Texas, United States of America

Corresponding Author

Email: Michael.holbrook@nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KKG MNW DR ANF MRH. Performed the experiments: KKG MNW TLJ SLA AP ANF MRH. Analyzed the data: KKG MNW DR ANF MRH. Contributed reagents/materials/analysis tools: DR MRH. Wrote the paper: KKG DR ANF MRH.